Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor

Packaging of viral DNA depends on strong molecular motors that are powered by ATP hydrolysis. Here, the authors develop a single-molecule assay to monitor how nucleotide binding regulates motor-DNA interactions and reveal a generic mechanism that prevents exit of the whole DNA from the viral capsid...

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Autores principales:	Mariam Ordyan, Istiaq Alam, Marthandan Mahalingam, Venigalla B. Rao, Douglas E. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc126e59f18749f3a507075d720aa3b3
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spelling	oai:doaj.org-article:bc126e59f18749f3a507075d720aa3b32021-12-02T14:39:07ZNucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor10.1038/s41467-018-07834-22041-1723https://doaj.org/article/bc126e59f18749f3a507075d720aa3b32018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07834-2https://doaj.org/toc/2041-1723Packaging of viral DNA depends on strong molecular motors that are powered by ATP hydrolysis. Here, the authors develop a single-molecule assay to monitor how nucleotide binding regulates motor-DNA interactions and reveal a generic mechanism that prevents exit of the whole DNA from the viral capsid during packaging.Mariam OrdyanIstiaq AlamMarthandan MahalingamVenigalla B. RaoDouglas E. SmithNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariam Ordyan Istiaq Alam Marthandan Mahalingam Venigalla B. Rao Douglas E. Smith Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
description	Packaging of viral DNA depends on strong molecular motors that are powered by ATP hydrolysis. Here, the authors develop a single-molecule assay to monitor how nucleotide binding regulates motor-DNA interactions and reveal a generic mechanism that prevents exit of the whole DNA from the viral capsid during packaging.
format	article
author	Mariam Ordyan Istiaq Alam Marthandan Mahalingam Venigalla B. Rao Douglas E. Smith
author_facet	Mariam Ordyan Istiaq Alam Marthandan Mahalingam Venigalla B. Rao Douglas E. Smith
author_sort	Mariam Ordyan
title	Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
title_short	Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
title_full	Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
title_fullStr	Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
title_full_unstemmed	Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor
title_sort	nucleotide-dependent dna gripping and an end-clamp mechanism regulate the bacteriophage t4 viral packaging motor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bc126e59f18749f3a507075d720aa3b3
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Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor

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