Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

IL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eirini Giannoudaki, Yasmina E. Hernandez-Santana, Kelly Mulfaul, Sarah L. Doyle, Emily Hams, Padraic G. Fallon, Arimin Mat, Donal O’Shea, Manfred Kopf, Andrew E. Hogan, Patrick T. Walsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc1452cbf30c4db3ab7be1abbb926ebf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc1452cbf30c4db3ab7be1abbb926ebf
record_format	dspace
spelling	oai:doaj.org-article:bc1452cbf30c4db3ab7be1abbb926ebf2021-12-02T15:35:02ZInterleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction10.1038/s41467-019-11944-w2041-1723https://doaj.org/article/bc1452cbf30c4db3ab7be1abbb926ebf2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11944-whttps://doaj.org/toc/2041-1723IL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on intestinal microbiota.Eirini GiannoudakiYasmina E. Hernandez-SantanaKelly MulfaulSarah L. DoyleEmily HamsPadraic G. FallonArimin MatDonal O’SheaManfred KopfAndrew E. HoganPatrick T. WalshNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eirini Giannoudaki Yasmina E. Hernandez-Santana Kelly Mulfaul Sarah L. Doyle Emily Hams Padraic G. Fallon Arimin Mat Donal O’Shea Manfred Kopf Andrew E. Hogan Patrick T. Walsh Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
description	IL-36α,β and ɣ are IL-1-related cytokines promoting inflammation in the skin and intestine. Here the authors show they are elevated in individuals with obesity, and that mice lacking the IL-36 receptor antagonist are more resistant to diet-induced obesity and metabolic dysfunction, which depends on intestinal microbiota.
format	article
author	Eirini Giannoudaki Yasmina E. Hernandez-Santana Kelly Mulfaul Sarah L. Doyle Emily Hams Padraic G. Fallon Arimin Mat Donal O’Shea Manfred Kopf Andrew E. Hogan Patrick T. Walsh
author_facet	Eirini Giannoudaki Yasmina E. Hernandez-Santana Kelly Mulfaul Sarah L. Doyle Emily Hams Padraic G. Fallon Arimin Mat Donal O’Shea Manfred Kopf Andrew E. Hogan Patrick T. Walsh
author_sort	Eirini Giannoudaki
title	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_short	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_full	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_fullStr	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_full_unstemmed	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
title_sort	interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bc1452cbf30c4db3ab7be1abbb926ebf
work_keys_str_mv	AT eirinigiannoudaki interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT yasminaehernandezsantana interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT kellymulfaul interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT sarahldoyle interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT emilyhams interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT padraicgfallon interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT ariminmat interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT donaloshea interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT manfredkopf interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT andrewehogan interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction AT patricktwalsh interleukin36cytokinesaltertheintestinalmicrobiomeandcanprotectagainstobesityandmetabolicdysfunction
_version_	1718386678830202880

Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction

Ejemplares similares