Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity

Ayman El-Faham,1,2 Ahmed A Elzatahry,1,3 Zeid A Al-Othman,1 Elsayed Ahmed Elsayed4,5 1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, Alexandria, Egypt; 3Polymer Materials Resear...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	El-Faham A, Elzatahry AA, Al-Othman ZA, Elsayed EA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bc14f1ec34ed483e9ecb66ba1ffa7c9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc14f1ec34ed483e9ecb66ba1ffa7c9e
record_format	dspace
spelling	oai:doaj.org-article:bc14f1ec34ed483e9ecb66ba1ffa7c9e2021-12-02T02:10:28ZFacile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity1178-2013https://doaj.org/article/bc14f1ec34ed483e9ecb66ba1ffa7c9e2014-03-01T00:00:00Zhttp://www.dovepress.com/facile-method-for-the-synthesis-of-silver-nanoparticles-using-3-hydraz-a16018https://doaj.org/toc/1178-2013 Ayman El-Faham,1,2 Ahmed A Elzatahry,1,3 Zeid A Al-Othman,1 Elsayed Ahmed Elsayed4,5 1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, Alexandria, Egypt; 3Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technology Applications, New Borg El-Arab City, Alexandria, Egypt; 4Bioproducts Research Chair, Zoology Department, Faculty of Science, King Saud University, Saudi Arabia; 5Natural and Microbial Products Department, National Research Centre, Dokki, Cairo, Egypt Introduction: A new method for preparation of silver nanoparticles (AgNPs) based on using hydrazino-isatin derivatives in an aqueous methanol reaction medium is reported here. AgNPs were prepared using silver nitrate solubilized in a water core as the source of silver ions and 3-hydrazino-isatin derivatives (3-hydrazino-isatin [IsH] and 1-benzyl-3-hydrazino-isatin [BIsH]) solubilized in methanol core as a reducing agent. The proposed method is effective, rapid, and convenient. X-ray diffraction (XRD), energy dispersive X-ray analysis, scanning electron microscope (SEM) and transmission electron microscopy (TEM) were used for characterization of the AgNPs. The TEM micrographs confirmed that the nanopowders consist of well-dispersed agglomerates of grains with a narrow size distribution of 18–21 nm and 17–20 nm. The AgNPs, as well as BIsH, showed high antimicrobial and bactericidal activity against the Gram-positive Bacillus subtilis and Gram-negative Micrococcus luteus and Proteus vulgaris, as well as antifungal activities against Saccharomyces cerevisiae. On the other hand, they were not effective against the Gram-negative Escherichia coli. Purpose: A simple, effective, rapid, and convenient chemical reduction method for the synthesis of AgNPs in an aqueous methanol reaction medium using hydrazino-isatin derivatives and studying their antibacterial effect. Results: IsH and BIsH are remarkably powerful reductants for Ag+ ions in an aqueous methanol medium, which could be considered as a simple chemical reduction method for formation of AgNPs. The AgNP formation depends on the solubility of the hydrazino-isatin derivatives. BIsH gave more AgNPs than IsH, as observed from XRD. The formation of AgNPs is attributed to the adsorption of hydrazine derivatives and/or interparticle interaction on the surface of AgNP through electrostatic interactions between the lone pair electrons of the hydrazino group (C=N-NH2) and the positive surface of AgNPs. AgNPs and BIsH showed high antimicrobial and bacterial activity. Conclusion: In summary, it is shown that IsH and BIsH are remarkably powerful reductants for Ag+ ions in an aqueous methanol medium. BIsH gave more AgNPs than IsH, as observed from XRD due to better solubility of the BIsH than IsH in aqueous-methanol. The formation of AgNPs is attributed to the adsorption of hydrazine derivatives and/or interparticle interaction on the surface of AgNPs through electrostatic interactions between the lone pair electrons of the hydrazino group (C=N-NH2) and the positive surface of AgNPs. The AgNps as well as BIsH ligand showed high antimicrobial and bactericidal activity. Keywords: silver nanoparticles, 1-benzyl-3-hydrazinoisatin, SEM, TEM, antimicrobialEl-Faham AElzatahry AAAl-Othman ZAElsayed EADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1167-1174 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 El-Faham A Elzatahry AA Al-Othman ZA Elsayed EA Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
description	Ayman El-Faham,1,2 Ahmed A Elzatahry,1,3 Zeid A Al-Othman,1 Elsayed Ahmed Elsayed4,5 1Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, Alexandria, Egypt; 3Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technology Applications, New Borg El-Arab City, Alexandria, Egypt; 4Bioproducts Research Chair, Zoology Department, Faculty of Science, King Saud University, Saudi Arabia; 5Natural and Microbial Products Department, National Research Centre, Dokki, Cairo, Egypt Introduction: A new method for preparation of silver nanoparticles (AgNPs) based on using hydrazino-isatin derivatives in an aqueous methanol reaction medium is reported here. AgNPs were prepared using silver nitrate solubilized in a water core as the source of silver ions and 3-hydrazino-isatin derivatives (3-hydrazino-isatin [IsH] and 1-benzyl-3-hydrazino-isatin [BIsH]) solubilized in methanol core as a reducing agent. The proposed method is effective, rapid, and convenient. X-ray diffraction (XRD), energy dispersive X-ray analysis, scanning electron microscope (SEM) and transmission electron microscopy (TEM) were used for characterization of the AgNPs. The TEM micrographs confirmed that the nanopowders consist of well-dispersed agglomerates of grains with a narrow size distribution of 18–21 nm and 17–20 nm. The AgNPs, as well as BIsH, showed high antimicrobial and bactericidal activity against the Gram-positive Bacillus subtilis and Gram-negative Micrococcus luteus and Proteus vulgaris, as well as antifungal activities against Saccharomyces cerevisiae. On the other hand, they were not effective against the Gram-negative Escherichia coli. Purpose: A simple, effective, rapid, and convenient chemical reduction method for the synthesis of AgNPs in an aqueous methanol reaction medium using hydrazino-isatin derivatives and studying their antibacterial effect. Results: IsH and BIsH are remarkably powerful reductants for Ag+ ions in an aqueous methanol medium, which could be considered as a simple chemical reduction method for formation of AgNPs. The AgNP formation depends on the solubility of the hydrazino-isatin derivatives. BIsH gave more AgNPs than IsH, as observed from XRD. The formation of AgNPs is attributed to the adsorption of hydrazine derivatives and/or interparticle interaction on the surface of AgNP through electrostatic interactions between the lone pair electrons of the hydrazino group (C=N-NH2) and the positive surface of AgNPs. AgNPs and BIsH showed high antimicrobial and bacterial activity. Conclusion: In summary, it is shown that IsH and BIsH are remarkably powerful reductants for Ag+ ions in an aqueous methanol medium. BIsH gave more AgNPs than IsH, as observed from XRD due to better solubility of the BIsH than IsH in aqueous-methanol. The formation of AgNPs is attributed to the adsorption of hydrazine derivatives and/or interparticle interaction on the surface of AgNPs through electrostatic interactions between the lone pair electrons of the hydrazino group (C=N-NH2) and the positive surface of AgNPs. The AgNps as well as BIsH ligand showed high antimicrobial and bactericidal activity. Keywords: silver nanoparticles, 1-benzyl-3-hydrazinoisatin, SEM, TEM, antimicrobial
format	article
author	El-Faham A Elzatahry AA Al-Othman ZA Elsayed EA
author_facet	El-Faham A Elzatahry AA Al-Othman ZA Elsayed EA
author_sort	El-Faham A
title	Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
title_short	Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
title_full	Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
title_fullStr	Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
title_full_unstemmed	Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
title_sort	facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/bc14f1ec34ed483e9ecb66ba1ffa7c9e
work_keys_str_mv	AT elfahama facilemethodforthesynthesisofsilvernanoparticlesusing3hydrazinoisatinderivativesinaqueousmethanolandtheirantibacterialactivity AT elzatahryaa facilemethodforthesynthesisofsilvernanoparticlesusing3hydrazinoisatinderivativesinaqueousmethanolandtheirantibacterialactivity AT alothmanza facilemethodforthesynthesisofsilvernanoparticlesusing3hydrazinoisatinderivativesinaqueousmethanolandtheirantibacterialactivity AT elsayedea facilemethodforthesynthesisofsilvernanoparticlesusing3hydrazinoisatinderivativesinaqueousmethanolandtheirantibacterialactivity
_version_	1718402674799411200

Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity

Ejemplares similares