O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Post-translational modifications of phosphoglycerate kinase 1 (PGK1), a glycoytic enzyme, contribute to cancer progression. Here, the authors show that PGK1 is O-GlcNAcylated at T255, which induces its translocation into mitochondria to suppress the tricarboxylic acid cycle for colorectal cancer gro...

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Autores principales:	Hao Nie, Haixing Ju, Jiayi Fan, Xiaoliu Shi, Yaxian Cheng, Xiaohui Cang, Zhiguo Zheng, Xiaotao Duan, Wen Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc18ea8990ad46b4ab1513f00960408e
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spelling	oai:doaj.org-article:bc18ea8990ad46b4ab1513f00960408e2021-12-02T17:31:08ZO-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth10.1038/s41467-019-13601-82041-1723https://doaj.org/article/bc18ea8990ad46b4ab1513f00960408e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13601-8https://doaj.org/toc/2041-1723Post-translational modifications of phosphoglycerate kinase 1 (PGK1), a glycoytic enzyme, contribute to cancer progression. Here, the authors show that PGK1 is O-GlcNAcylated at T255, which induces its translocation into mitochondria to suppress the tricarboxylic acid cycle for colorectal cancer growth.Hao NieHaixing JuJiayi FanXiaoliu ShiYaxian ChengXiaohui CangZhiguo ZhengXiaotao DuanWen YiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Nie Haixing Ju Jiayi Fan Xiaoliu Shi Yaxian Cheng Xiaohui Cang Zhiguo Zheng Xiaotao Duan Wen Yi O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
description	Post-translational modifications of phosphoglycerate kinase 1 (PGK1), a glycoytic enzyme, contribute to cancer progression. Here, the authors show that PGK1 is O-GlcNAcylated at T255, which induces its translocation into mitochondria to suppress the tricarboxylic acid cycle for colorectal cancer growth.
format	article
author	Hao Nie Haixing Ju Jiayi Fan Xiaoliu Shi Yaxian Cheng Xiaohui Cang Zhiguo Zheng Xiaotao Duan Wen Yi
author_facet	Hao Nie Haixing Ju Jiayi Fan Xiaoliu Shi Yaxian Cheng Xiaohui Cang Zhiguo Zheng Xiaotao Duan Wen Yi
author_sort	Hao Nie
title	O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
title_short	O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
title_full	O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
title_fullStr	O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
title_full_unstemmed	O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
title_sort	o-glcnacylation of pgk1 coordinates glycolysis and tca cycle to promote tumor growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bc18ea8990ad46b4ab1513f00960408e
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O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

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