An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis

Abstract Background Adrenal tuberculosis is difficult to diagnose due to non-specific symptom. Unexpected death due to adrenal insufficiency after trauma surgery is rare. Case presentation A 45-year-old man, who was admitted to hospital because of trauma to the right hand, died unexpectedly on the 1...

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Autores principales:	Nan Zhao, Yutong Gao, Chunsheng Ni, Danfang Zhang, Xiulan Zhao, Yanlei Li, Baocun Sun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Adrenal crisis Pulmonary tuberculosis Adrenal tuberculosis Medicine R
Acceso en línea:	https://doaj.org/article/bc1a52d468f0481c9d92de20b5d22f23
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spelling	oai:doaj.org-article:bc1a52d468f0481c9d92de20b5d22f232021-12-05T12:17:42ZAn autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis10.1186/s40001-021-00611-w2047-783Xhttps://doaj.org/article/bc1a52d468f0481c9d92de20b5d22f232021-12-01T00:00:00Zhttps://doi.org/10.1186/s40001-021-00611-whttps://doaj.org/toc/2047-783XAbstract Background Adrenal tuberculosis is difficult to diagnose due to non-specific symptom. Unexpected death due to adrenal insufficiency after trauma surgery is rare. Case presentation A 45-year-old man, who was admitted to hospital because of trauma to the right hand, died unexpectedly on the 13th day after replantation of amputated fingers. He was diagnosed with brain edema and diluted hyponatremia. Autopsy and histopathologic examination revealed severe brain edema combined with cerebellar tonsillar hernia, extensive destruction of adrenal gland caused by bilateral adrenal tuberculosis and right lung invasive pulmonary tuberculosis. Conclusions Trauma and pulmonary tuberculosis complicated with adrenal tuberculosis induced the adrenal crisis, which eventually lead to severe cerebral edema and hernia, and finally death from respiratory and circulatory failure. This autopsy and histopathologic examination suggested a possible pathophysiologic mechanism of sudden death due to diluted hyponatremia after trauma surgery.Nan ZhaoYutong GaoChunsheng NiDanfang ZhangXiulan ZhaoYanlei LiBaocun SunBMCarticleAdrenal crisisPulmonary tuberculosisAdrenal tuberculosisMedicineRENEuropean Journal of Medical Research, Vol 26, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adrenal crisis Pulmonary tuberculosis Adrenal tuberculosis Medicine R
spellingShingle	Adrenal crisis Pulmonary tuberculosis Adrenal tuberculosis Medicine R Nan Zhao Yutong Gao Chunsheng Ni Danfang Zhang Xiulan Zhao Yanlei Li Baocun Sun An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
description	Abstract Background Adrenal tuberculosis is difficult to diagnose due to non-specific symptom. Unexpected death due to adrenal insufficiency after trauma surgery is rare. Case presentation A 45-year-old man, who was admitted to hospital because of trauma to the right hand, died unexpectedly on the 13th day after replantation of amputated fingers. He was diagnosed with brain edema and diluted hyponatremia. Autopsy and histopathologic examination revealed severe brain edema combined with cerebellar tonsillar hernia, extensive destruction of adrenal gland caused by bilateral adrenal tuberculosis and right lung invasive pulmonary tuberculosis. Conclusions Trauma and pulmonary tuberculosis complicated with adrenal tuberculosis induced the adrenal crisis, which eventually lead to severe cerebral edema and hernia, and finally death from respiratory and circulatory failure. This autopsy and histopathologic examination suggested a possible pathophysiologic mechanism of sudden death due to diluted hyponatremia after trauma surgery.
format	article
author	Nan Zhao Yutong Gao Chunsheng Ni Danfang Zhang Xiulan Zhao Yanlei Li Baocun Sun
author_facet	Nan Zhao Yutong Gao Chunsheng Ni Danfang Zhang Xiulan Zhao Yanlei Li Baocun Sun
author_sort	Nan Zhao
title	An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_short	An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_full	An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_fullStr	An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_full_unstemmed	An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_sort	autopsy case of unexpected death due to addison’s disease caused by adrenal tuberculosis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bc1a52d468f0481c9d92de20b5d22f23
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An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis

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