Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children

Background: <a title="Learn more about Helminthiasis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/helminthiasis">Helminth infection</a> is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells,...

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Auteurs principaux:	Ganiyu Olatunbosun Arinola, Olajumoke Abimbola Morenikeji, Kazeem Sanjo Akinwande, Ayodele Olasoji Alade, Oluwakemi Olateru-Olagbegi, Ponmile Emmanuel Alabi, Sheu Kadiri Rahamon
Format:	article
Langue:	EN
Publié:	Ubiquity Press 2016
Sujets:	children cytokines helminth infection IgE pregnant women Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Accès en ligne:	https://doaj.org/article/bc1b37788a1f40be87b13e8e6d45ca5b
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spelling	oai:doaj.org-article:bc1b37788a1f40be87b13e8e6d45ca5b2021-12-02T04:05:10ZSerum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children2214-999610.1016/j.aogh.2015.12.008https://doaj.org/article/bc1b37788a1f40be87b13e8e6d45ca5b2016-03-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/1472https://doaj.org/toc/2214-9996Background: <a title="Learn more about Helminthiasis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/helminthiasis">Helminth infection</a> is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic interplay that manifest during the coexistence of helminth infection with other conditions is still poorly understood. Objective: This study determined the pattern of alteration in selected <a title="Learn more about Cytokines" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cytokines">cytokines</a> and <a title="Learn more about Immunoglobulin E" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunoglobulin-e">immunoglobulin E</a>(IgE) in pregnant women, preschool aged children, and school-aged children with helminth infection compared with uninfected groups. Methods: Seventeen pregnant women, 42 preschool-aged children, and 60 school-aged children with helminth infection (HI) were recruited into this study. They were matched with 21 pregnant women, 42 preschool-aged children, and 50 school-aged children without helminth infection (HN) who served as controls. <a title="Learn more about Venous blood" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/venous-blood">Venous blood</a> samples were collected from each participant and analyzed for serum levels of <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">tumor necrosis factor</a> α (TNF-α), interleukin-10 (IL-10), <a title="Learn more about Interleukin-8" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-8">interleukin-8</a> (IL-8), <a title="Learn more about Interleukin-6" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-6">interleukin-6</a> (IL-6), and IgE. Statistical analysis was done using the Student 't' test, and 'P' < .05 was considered as statistically significant. Findings: Only serum level of IgE was significantly elevated in HI pregnant women compared with HN pregnant women. In HI preschool- and school-aged children, serum levels of IL-8, IL-6, and IgE were significantly elevated compared with HN children. However, preschool- and school-aged children with HI had similar levels of serum TNF-α and IL-10 compared with their corresponding HN groups. Conclusions: It could be concluded that altered cytokines expression in children and pregnant women with helminth infection might have some implications on need for deworming programs to improve pregnancy outcomes and vaccine responses.Ganiyu Olatunbosun ArinolaOlajumoke Abimbola MorenikejiKazeem Sanjo AkinwandeAyodele Olasoji AladeOluwakemi Olateru-OlagbegiPonmile Emmanuel AlabiSheu Kadiri RahamonUbiquity Pressarticlechildrencytokineshelminth infectionIgEpregnant womenInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 81, Iss 5, Pp 689-693 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	children cytokines helminth infection IgE pregnant women Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	children cytokines helminth infection IgE pregnant women Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Ganiyu Olatunbosun Arinola Olajumoke Abimbola Morenikeji Kazeem Sanjo Akinwande Ayodele Olasoji Alade Oluwakemi Olateru-Olagbegi Ponmile Emmanuel Alabi Sheu Kadiri Rahamon Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
description	Background: <a title="Learn more about Helminthiasis" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/helminthiasis">Helminth infection</a> is an important health challenge. Because of modulation of the immune response toward T-helper 2 (Th2) cells, the immunologic interplay that manifest during the coexistence of helminth infection with other conditions is still poorly understood. Objective: This study determined the pattern of alteration in selected <a title="Learn more about Cytokines" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/cytokines">cytokines</a> and <a title="Learn more about Immunoglobulin E" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/immunoglobulin-e">immunoglobulin E</a>(IgE) in pregnant women, preschool aged children, and school-aged children with helminth infection compared with uninfected groups. Methods: Seventeen pregnant women, 42 preschool-aged children, and 60 school-aged children with helminth infection (HI) were recruited into this study. They were matched with 21 pregnant women, 42 preschool-aged children, and 50 school-aged children without helminth infection (HN) who served as controls. <a title="Learn more about Venous blood" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/venous-blood">Venous blood</a> samples were collected from each participant and analyzed for serum levels of <a title="Learn more about Tumor Necrosis Factor" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tumor-necrosis-factor">tumor necrosis factor</a> α (TNF-α), interleukin-10 (IL-10), <a title="Learn more about Interleukin-8" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-8">interleukin-8</a> (IL-8), <a title="Learn more about Interleukin-6" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/interleukin-6">interleukin-6</a> (IL-6), and IgE. Statistical analysis was done using the Student 't' test, and 'P' < .05 was considered as statistically significant. Findings: Only serum level of IgE was significantly elevated in HI pregnant women compared with HN pregnant women. In HI preschool- and school-aged children, serum levels of IL-8, IL-6, and IgE were significantly elevated compared with HN children. However, preschool- and school-aged children with HI had similar levels of serum TNF-α and IL-10 compared with their corresponding HN groups. Conclusions: It could be concluded that altered cytokines expression in children and pregnant women with helminth infection might have some implications on need for deworming programs to improve pregnancy outcomes and vaccine responses.
format	article
author	Ganiyu Olatunbosun Arinola Olajumoke Abimbola Morenikeji Kazeem Sanjo Akinwande Ayodele Olasoji Alade Oluwakemi Olateru-Olagbegi Ponmile Emmanuel Alabi Sheu Kadiri Rahamon
author_facet	Ganiyu Olatunbosun Arinola Olajumoke Abimbola Morenikeji Kazeem Sanjo Akinwande Ayodele Olasoji Alade Oluwakemi Olateru-Olagbegi Ponmile Emmanuel Alabi Sheu Kadiri Rahamon
author_sort	Ganiyu Olatunbosun Arinola
title	Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
title_short	Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
title_full	Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
title_fullStr	Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
title_full_unstemmed	Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children
title_sort	serum levels of cytokines and ige in helminth-infected nigerian pregnant women and children
publisher	Ubiquity Press
publishDate	2016
url	https://doaj.org/article/bc1b37788a1f40be87b13e8e6d45ca5b
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Serum Levels of Cytokines and IgE in Helminth-Infected Nigerian Pregnant Women and Children

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