The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations

The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations

Chromosomal translocations involving the AF10 gene, especially with CALM, are associated with aggressive leukemias. Here the authors show that the PZP domain of AF10, a histone reader, is always excluded/impaired in AF10 fusions, whereas incorporation of this domain downregulates Hoxa genes and bloc...

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Autores principales: Brianna J. Klein, Anagha Deshpande, Khan L. Cox, Fan Xuan, Mohamad Zandian, Karina Barbosa, Sujita Khanal, Qiong Tong, Yi Zhang, Pan Zhang, Amit Sinha, Stefan K. Bohlander, Xiaobing Shi, Hong Wen, Michael G. Poirier, Aniruddha J. Deshpande, Tatiana G. Kutateladze
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bc1ee92ef2674d4cb5c121a8d5e098c2
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spelling oai:doaj.org-article:bc1ee92ef2674d4cb5c121a8d5e098c22021-12-02T15:40:02ZThe role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations10.1038/s41467-021-24418-92041-1723https://doaj.org/article/bc1ee92ef2674d4cb5c121a8d5e098c22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24418-9https://doaj.org/toc/2041-1723Chromosomal translocations involving the AF10 gene, especially with CALM, are associated with aggressive leukemias. Here the authors show that the PZP domain of AF10, a histone reader, is always excluded/impaired in AF10 fusions, whereas incorporation of this domain downregulates Hoxa genes and blocks leukemogenesis.Brianna J. KleinAnagha DeshpandeKhan L. CoxFan XuanMohamad ZandianKarina BarbosaSujita KhanalQiong TongYi ZhangPan ZhangAmit SinhaStefan K. BohlanderXiaobing ShiHong WenMichael G. PoirierAniruddha J. DeshpandeTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Brianna J. Klein
Anagha Deshpande
Khan L. Cox
Fan Xuan
Mohamad Zandian
Karina Barbosa
Sujita Khanal
Qiong Tong
Yi Zhang
Pan Zhang
Amit Sinha
Stefan K. Bohlander
Xiaobing Shi
Hong Wen
Michael G. Poirier
Aniruddha J. Deshpande
Tatiana G. Kutateladze
The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
description Chromosomal translocations involving the AF10 gene, especially with CALM, are associated with aggressive leukemias. Here the authors show that the PZP domain of AF10, a histone reader, is always excluded/impaired in AF10 fusions, whereas incorporation of this domain downregulates Hoxa genes and blocks leukemogenesis.
format article
author Brianna J. Klein
Anagha Deshpande
Khan L. Cox
Fan Xuan
Mohamad Zandian
Karina Barbosa
Sujita Khanal
Qiong Tong
Yi Zhang
Pan Zhang
Amit Sinha
Stefan K. Bohlander
Xiaobing Shi
Hong Wen
Michael G. Poirier
Aniruddha J. Deshpande
Tatiana G. Kutateladze
author_facet Brianna J. Klein
Anagha Deshpande
Khan L. Cox
Fan Xuan
Mohamad Zandian
Karina Barbosa
Sujita Khanal
Qiong Tong
Yi Zhang
Pan Zhang
Amit Sinha
Stefan K. Bohlander
Xiaobing Shi
Hong Wen
Michael G. Poirier
Aniruddha J. Deshpande
Tatiana G. Kutateladze
author_sort Brianna J. Klein
title The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
title_short The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
title_full The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
title_fullStr The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
title_full_unstemmed The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations
title_sort role of the pzp domain of af10 in acute leukemia driven by af10 translocations
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bc1ee92ef2674d4cb5c121a8d5e098c2
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