Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage

Abstract Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consiste...

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Autores principales:	Lexuri Fernández de Gamarra-Oca, Leire Zubiaurre-Elorza, Carme Junqué, Elisabeth Solana, Sara Soria-Pastor, Élida Vázquez, Ignacio Delgado, Alfons Macaya, Natalia Ojeda, Maria A. Poca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc207ba0d7e9470a83ebf8cdde76cbc5
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spelling	oai:doaj.org-article:bc207ba0d7e9470a83ebf8cdde76cbc52021-12-02T13:57:59ZReduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage10.1038/s41598-021-81802-72045-2322https://doaj.org/article/bc207ba0d7e9470a83ebf8cdde76cbc52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81802-7https://doaj.org/toc/2045-2322Abstract Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced significantly lower total hippocampal volumes bilaterally and hippocampal subfield volumes compared to both low-risk preterm and full-term groups. Finally, significant positive correlations between memory and hippocampal subfield volumes were only found in preterm participants together; memory and the right CA-field correlation remained significant after Bonferroni correction was applied (p = .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifically related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-field volume and memory during childhood.Lexuri Fernández de Gamarra-OcaLeire Zubiaurre-ElorzaCarme JunquéElisabeth SolanaSara Soria-PastorÉlida VázquezIgnacio DelgadoAlfons MacayaNatalia OjedaMaria A. PocaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lexuri Fernández de Gamarra-Oca Leire Zubiaurre-Elorza Carme Junqué Elisabeth Solana Sara Soria-Pastor Élida Vázquez Ignacio Delgado Alfons Macaya Natalia Ojeda Maria A. Poca Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
description	Abstract Preterm newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) are at a higher risk of evidencing neurodevelopmental alterations. Present study aimed to explore the long-term effects that GM-IVH have on hippocampal subfields, and their correlates with memory. The sample consisted of 58 participants, including 36 preterm-born (16 with GM-IVH and 20 without neonatal brain injury), and 22 full-term children aged between 6 and 15 years old. All participants underwent a cognitive assessment and magnetic resonance imaging study. GM-IVH children evidenced lower scores in Full Intelligence Quotient and memory measures compared to their low-risk preterm and full-term peers. High-risk preterm children with GM-IVH evidenced significantly lower total hippocampal volumes bilaterally and hippocampal subfield volumes compared to both low-risk preterm and full-term groups. Finally, significant positive correlations between memory and hippocampal subfield volumes were only found in preterm participants together; memory and the right CA-field correlation remained significant after Bonferroni correction was applied (p = .002). In conclusion, memory alterations and both global and regional volumetric reductions in the hippocampus were found to be specifically related to a preterm sample with GM-IVH. Nevertheless, results also suggest that prematurity per se has a long-lasting impact on the association between the right CA-field volume and memory during childhood.
format	article
author	Lexuri Fernández de Gamarra-Oca Leire Zubiaurre-Elorza Carme Junqué Elisabeth Solana Sara Soria-Pastor Élida Vázquez Ignacio Delgado Alfons Macaya Natalia Ojeda Maria A. Poca
author_facet	Lexuri Fernández de Gamarra-Oca Leire Zubiaurre-Elorza Carme Junqué Elisabeth Solana Sara Soria-Pastor Élida Vázquez Ignacio Delgado Alfons Macaya Natalia Ojeda Maria A. Poca
author_sort	Lexuri Fernández de Gamarra-Oca
title	Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_short	Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_full	Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_fullStr	Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_full_unstemmed	Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
title_sort	reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc207ba0d7e9470a83ebf8cdde76cbc5
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Reduced hippocampal subfield volumes and memory performance in preterm children with and without germinal matrix-intraventricular hemorrhage

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