Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS...

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Autores principales:	Divya Jain, Yogesh Murti, Wasi Ullah Khan, Rajib Hossain, Mohammad Nabil Hossain, Krishn Kumar Agrawal, Rana Azeem Ashraf, Muhammad Torequl Islam, Pracheta Janmeda, Yasaman Taheri, Mohammed M. Alshehri, Sevgi Durna Daştan, Balakyz Yeskaliyeva, Aliya Kipchakbayeva, Javad Sharifi-Rad, William C. Cho
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/bc227e8c51434f21939a5dc61a334fc9
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spelling	oai:doaj.org-article:bc227e8c51434f21939a5dc61a334fc92021-11-08T02:35:36ZRoles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma1942-099410.1155/2021/9068850https://doaj.org/article/bc227e8c51434f21939a5dc61a334fc92021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9068850https://doaj.org/toc/1942-0994Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.Divya JainYogesh MurtiWasi Ullah KhanRajib HossainMohammad Nabil HossainKrishn Kumar AgrawalRana Azeem AshrafMuhammad Torequl IslamPracheta JanmedaYasaman TaheriMohammed M. AlshehriSevgi Durna DaştanBalakyz YeskaliyevaAliya KipchakbayevaJavad Sharifi-RadWilliam C. ChoHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Divya Jain Yogesh Murti Wasi Ullah Khan Rajib Hossain Mohammad Nabil Hossain Krishn Kumar Agrawal Rana Azeem Ashraf Muhammad Torequl Islam Pracheta Janmeda Yasaman Taheri Mohammed M. Alshehri Sevgi Durna Daştan Balakyz Yeskaliyeva Aliya Kipchakbayeva Javad Sharifi-Rad William C. Cho Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.
format	article
author	Divya Jain Yogesh Murti Wasi Ullah Khan Rajib Hossain Mohammad Nabil Hossain Krishn Kumar Agrawal Rana Azeem Ashraf Muhammad Torequl Islam Pracheta Janmeda Yasaman Taheri Mohammed M. Alshehri Sevgi Durna Daştan Balakyz Yeskaliyeva Aliya Kipchakbayeva Javad Sharifi-Rad William C. Cho
author_facet	Divya Jain Yogesh Murti Wasi Ullah Khan Rajib Hossain Mohammad Nabil Hossain Krishn Kumar Agrawal Rana Azeem Ashraf Muhammad Torequl Islam Pracheta Janmeda Yasaman Taheri Mohammed M. Alshehri Sevgi Durna Daştan Balakyz Yeskaliyeva Aliya Kipchakbayeva Javad Sharifi-Rad William C. Cho
author_sort	Divya Jain
title	Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
title_short	Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
title_full	Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
title_fullStr	Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
title_full_unstemmed	Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
title_sort	roles of therapeutic bioactive compounds in hepatocellular carcinoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/bc227e8c51434f21939a5dc61a334fc9
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Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

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