Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of neural progenitor cells via transcriptional regulat...

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Autores principales:	Luis Zurkirchen, Sandra Varum, Sonja Giger, Annika Klug, Jessica Häusel, Raphaël Bossart, Martina Zemke, Claudio Cantù, Zeynep Kalender Atak, Nicola Zamboni, Konrad Basler, Lukas Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc26cd50490644df85c84964bd1b920a
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spelling	oai:doaj.org-article:bc26cd50490644df85c84964bd1b920a2021-12-02T17:02:16ZYin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner10.1038/s41467-019-09823-52041-1723https://doaj.org/article/bc26cd50490644df85c84964bd1b920a2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09823-5https://doaj.org/toc/2041-1723The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of neural progenitor cells via transcriptional regulation of genes involved in metabolism and protein translation.Luis ZurkirchenSandra VarumSonja GigerAnnika KlugJessica HäuselRaphaël BossartMartina ZemkeClaudio CantùZeynep Kalender AtakNicola ZamboniKonrad BaslerLukas SommerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luis Zurkirchen Sandra Varum Sonja Giger Annika Klug Jessica Häusel Raphaël Bossart Martina Zemke Claudio Cantù Zeynep Kalender Atak Nicola Zamboni Konrad Basler Lukas Sommer Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
description	The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of neural progenitor cells via transcriptional regulation of genes involved in metabolism and protein translation.
format	article
author	Luis Zurkirchen Sandra Varum Sonja Giger Annika Klug Jessica Häusel Raphaël Bossart Martina Zemke Claudio Cantù Zeynep Kalender Atak Nicola Zamboni Konrad Basler Lukas Sommer
author_facet	Luis Zurkirchen Sandra Varum Sonja Giger Annika Klug Jessica Häusel Raphaël Bossart Martina Zemke Claudio Cantù Zeynep Kalender Atak Nicola Zamboni Konrad Basler Lukas Sommer
author_sort	Luis Zurkirchen
title	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
title_short	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
title_full	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
title_fullStr	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
title_full_unstemmed	Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
title_sort	yin yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bc26cd50490644df85c84964bd1b920a
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Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

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