The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.

The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice. A total of thirty-six deep digital flexor (DDF) tendons in the third digits of each hind paw from eighteen adult mice...

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Autores principales:	Masanori Hayashi, Chunfeng Zhao, Andrew R Thoreson, Takako Chikenji, Gregory D Jay, Kai-Nan An, Peter C Amadio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc2865a3537d46ad932ced4331c1d604
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spelling	oai:doaj.org-article:bc2865a3537d46ad932ced4331c1d6042021-11-18T08:41:56ZThe effect of lubricin on the gliding resistance of mouse intrasynovial tendon.1932-620310.1371/journal.pone.0083836https://doaj.org/article/bc2865a3537d46ad932ced4331c1d6042013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349551/?tool=EBIhttps://doaj.org/toc/1932-6203The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice. A total of thirty-six deep digital flexor (DDF) tendons in the third digits of each hind paw from eighteen adult mice were used, including six lubricin knockout mice (Prg4 -/-), six heterozygous mice (Prg4 +/-), and six wild type mice (Prg4 +/+). The tendon gliding resistance was measured using a custom-made device. Tendon structural changes were evaluated by scanning electron and light microscopy. The gliding resistance of intrasynovial tendons from lubricin knockout mice was significantly higher than the gliding resistance of either wild type or heterozygous mice. The surface of the lubricin knockout tendons appeared to be rougher, compared to the wild type and heterozygous tendons. Synovial hyperplasia was found in the lubricin knockout mice. Cartilage-like tissue was found in the tendon and pulley of the lubricin knockout mice. Our findings confirm the importance of lubricin in intrasynovial tendon lubrication. This knockout model may be useful in determining the effect of lubricin on tendon healing and the response to injury.Masanori HayashiChunfeng ZhaoAndrew R ThoresonTakako ChikenjiGregory D JayKai-Nan AnPeter C AmadioPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83836 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masanori Hayashi Chunfeng Zhao Andrew R Thoreson Takako Chikenji Gregory D Jay Kai-Nan An Peter C Amadio The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
description	The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice. A total of thirty-six deep digital flexor (DDF) tendons in the third digits of each hind paw from eighteen adult mice were used, including six lubricin knockout mice (Prg4 -/-), six heterozygous mice (Prg4 +/-), and six wild type mice (Prg4 +/+). The tendon gliding resistance was measured using a custom-made device. Tendon structural changes were evaluated by scanning electron and light microscopy. The gliding resistance of intrasynovial tendons from lubricin knockout mice was significantly higher than the gliding resistance of either wild type or heterozygous mice. The surface of the lubricin knockout tendons appeared to be rougher, compared to the wild type and heterozygous tendons. Synovial hyperplasia was found in the lubricin knockout mice. Cartilage-like tissue was found in the tendon and pulley of the lubricin knockout mice. Our findings confirm the importance of lubricin in intrasynovial tendon lubrication. This knockout model may be useful in determining the effect of lubricin on tendon healing and the response to injury.
format	article
author	Masanori Hayashi Chunfeng Zhao Andrew R Thoreson Takako Chikenji Gregory D Jay Kai-Nan An Peter C Amadio
author_facet	Masanori Hayashi Chunfeng Zhao Andrew R Thoreson Takako Chikenji Gregory D Jay Kai-Nan An Peter C Amadio
author_sort	Masanori Hayashi
title	The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
title_short	The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
title_full	The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
title_fullStr	The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
title_full_unstemmed	The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
title_sort	effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bc2865a3537d46ad932ced4331c1d604
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The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.

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