Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome

<i>Background and Objectives</i>: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OS...

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Autores principales:	Athanasios Voulgaris, Kostas Archontogeorgis, Athanasia Pataka, Alexandros N. Flaris, Paschalis Ntolios, Maria R. Bonsignore, Sophia Schiza, Paschalis Steiropoulos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obstructive sleep apnea syndrome chronic obstructive pulmonary disease overlap syndrome comorbidities cardiovascular disease Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bc2ae2ed0e2549e3a03a17e3655e49e5
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spelling	oai:doaj.org-article:bc2ae2ed0e2549e3a03a17e3655e49e52021-11-25T18:18:32ZBurden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome10.3390/medicina571112011648-91441010-660Xhttps://doaj.org/article/bc2ae2ed0e2549e3a03a17e3655e49e52021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1201https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OSAS and COPD-OSAS overlap syndrome (OS) patients and to explore differences between these two groups. <i>Materials and Methods</i>: Included were consecutive OS patients and OSAS patients who had been referred to our sleep laboratory, and were matched in terms of sex, age, BMI, and smoking history. Presence of comorbidities was recorded based on their medical history and after clinical and laboratory examination. <i>Results</i>: The two groups, OS patients (<i>n</i> = 163, AHI > 5/h and FEV<sub>1</sub>/FVC < 0.7) and OSAS patients (<i>n</i> = 163, AHI > 5/h, and FEV<sub>1</sub>/FVC > 0.7), did not differ in terms of apnea hypopnea index (<i>p</i> = 0.346), and oxygen desaturation index (<i>p</i> = 0.668). Compared to OSAS patients, OS patients had lower average SpO<sub>2</sub> (<i>p</i> = 0.008) and higher sleep time with oxygen saturation <90% (<i>p</i> = 0.002) during sleep, and lower PaO<sub>2</sub> (<i>p</i> < 0.001) and higher PaCO<sub>2</sub> (<i>p</i> = 0.04) in wakefulness. Arterial hypertension was the most prevalent comorbidity for both OS and OSAS, followed by dyslipidemia, cardiovascular disease (CVD) and diabetes. OS was characterized by a higher prevalence of total comorbidities (median (IQR):2 (1–3) vs. 2 (1–2), <i>p</i> = 0.033), which was due to the higher prevalence of CVD (<i>p</i> = 0.016) than OSAS. No differences were observed in other comorbidities. <i>Conclusions</i>: In OS patients, nocturnal hypoxia and impaired gas exchange in wakefulness are more overt, while a higher burden of CVD is observed among them in comparison to sex-, age- and BMI-matched OSAS patients.Athanasios VoulgarisKostas ArchontogeorgisAthanasia PatakaAlexandros N. FlarisPaschalis NtoliosMaria R. BonsignoreSophia SchizaPaschalis SteiropoulosMDPI AGarticleobstructive sleep apnea syndromechronic obstructive pulmonary diseaseoverlap syndromecomorbiditiescardiovascular diseaseMedicine (General)R5-920ENMedicina, Vol 57, Iss 1201, p 1201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea syndrome chronic obstructive pulmonary disease overlap syndrome comorbidities cardiovascular disease Medicine (General) R5-920
spellingShingle	obstructive sleep apnea syndrome chronic obstructive pulmonary disease overlap syndrome comorbidities cardiovascular disease Medicine (General) R5-920 Athanasios Voulgaris Kostas Archontogeorgis Athanasia Pataka Alexandros N. Flaris Paschalis Ntolios Maria R. Bonsignore Sophia Schiza Paschalis Steiropoulos Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
description	<i>Background and Objectives</i>: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OSAS and COPD-OSAS overlap syndrome (OS) patients and to explore differences between these two groups. <i>Materials and Methods</i>: Included were consecutive OS patients and OSAS patients who had been referred to our sleep laboratory, and were matched in terms of sex, age, BMI, and smoking history. Presence of comorbidities was recorded based on their medical history and after clinical and laboratory examination. <i>Results</i>: The two groups, OS patients (<i>n</i> = 163, AHI > 5/h and FEV<sub>1</sub>/FVC < 0.7) and OSAS patients (<i>n</i> = 163, AHI > 5/h, and FEV<sub>1</sub>/FVC > 0.7), did not differ in terms of apnea hypopnea index (<i>p</i> = 0.346), and oxygen desaturation index (<i>p</i> = 0.668). Compared to OSAS patients, OS patients had lower average SpO<sub>2</sub> (<i>p</i> = 0.008) and higher sleep time with oxygen saturation <90% (<i>p</i> = 0.002) during sleep, and lower PaO<sub>2</sub> (<i>p</i> < 0.001) and higher PaCO<sub>2</sub> (<i>p</i> = 0.04) in wakefulness. Arterial hypertension was the most prevalent comorbidity for both OS and OSAS, followed by dyslipidemia, cardiovascular disease (CVD) and diabetes. OS was characterized by a higher prevalence of total comorbidities (median (IQR):2 (1–3) vs. 2 (1–2), <i>p</i> = 0.033), which was due to the higher prevalence of CVD (<i>p</i> = 0.016) than OSAS. No differences were observed in other comorbidities. <i>Conclusions</i>: In OS patients, nocturnal hypoxia and impaired gas exchange in wakefulness are more overt, while a higher burden of CVD is observed among them in comparison to sex-, age- and BMI-matched OSAS patients.
format	article
author	Athanasios Voulgaris Kostas Archontogeorgis Athanasia Pataka Alexandros N. Flaris Paschalis Ntolios Maria R. Bonsignore Sophia Schiza Paschalis Steiropoulos
author_facet	Athanasios Voulgaris Kostas Archontogeorgis Athanasia Pataka Alexandros N. Flaris Paschalis Ntolios Maria R. Bonsignore Sophia Schiza Paschalis Steiropoulos
author_sort	Athanasios Voulgaris
title	Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
title_short	Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
title_full	Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
title_fullStr	Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
title_full_unstemmed	Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
title_sort	burden of comorbidities in patients with osas and copd-osas overlap syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bc2ae2ed0e2549e3a03a17e3655e49e5
work_keys_str_mv	AT athanasiosvoulgaris burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT kostasarchontogeorgis burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT athanasiapataka burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT alexandrosnflaris burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT paschalisntolios burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT mariarbonsignore burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT sophiaschiza burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome AT paschalissteiropoulos burdenofcomorbiditiesinpatientswithosasandcopdosasoverlapsyndrome
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Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome

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