Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria

Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria

Perturbations of Ca2+ signaling in podocytes may deteriorate kidney function and eventually lead to proteinuria. Here the authors show that insulin can affect the function of the calcium regulator Ora1 in podocytes, which is critical for maintaining kidney filter integrity.

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Autores principales: Ji-Hee Kim, Kyu-Hee Hwang, Bao T. N. Dang, Minseob Eom, In Deok Kong, Yousang Gwack, Seyoung Yu, Heon Yung Gee, Lutz Birnbaumer, Kyu-Sang Park, Seung-Kuy Cha
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bc2e1cc7ee1947fb859dbac6a5b38a43
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spelling oai:doaj.org-article:bc2e1cc7ee1947fb859dbac6a5b38a432021-11-14T12:37:02ZInsulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria10.1038/s41467-021-26900-w2041-1723https://doaj.org/article/bc2e1cc7ee1947fb859dbac6a5b38a432021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26900-whttps://doaj.org/toc/2041-1723Perturbations of Ca2+ signaling in podocytes may deteriorate kidney function and eventually lead to proteinuria. Here the authors show that insulin can affect the function of the calcium regulator Ora1 in podocytes, which is critical for maintaining kidney filter integrity.Ji-Hee KimKyu-Hee HwangBao T. N. DangMinseob EomIn Deok KongYousang GwackSeyoung YuHeon Yung GeeLutz BirnbaumerKyu-Sang ParkSeung-Kuy ChaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ji-Hee Kim
Kyu-Hee Hwang
Bao T. N. Dang
Minseob Eom
In Deok Kong
Yousang Gwack
Seyoung Yu
Heon Yung Gee
Lutz Birnbaumer
Kyu-Sang Park
Seung-Kuy Cha
Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
description Perturbations of Ca2+ signaling in podocytes may deteriorate kidney function and eventually lead to proteinuria. Here the authors show that insulin can affect the function of the calcium regulator Ora1 in podocytes, which is critical for maintaining kidney filter integrity.
format article
author Ji-Hee Kim
Kyu-Hee Hwang
Bao T. N. Dang
Minseob Eom
In Deok Kong
Yousang Gwack
Seyoung Yu
Heon Yung Gee
Lutz Birnbaumer
Kyu-Sang Park
Seung-Kuy Cha
author_facet Ji-Hee Kim
Kyu-Hee Hwang
Bao T. N. Dang
Minseob Eom
In Deok Kong
Yousang Gwack
Seyoung Yu
Heon Yung Gee
Lutz Birnbaumer
Kyu-Sang Park
Seung-Kuy Cha
author_sort Ji-Hee Kim
title Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
title_short Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
title_full Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
title_fullStr Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
title_full_unstemmed Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria
title_sort insulin-activated store-operated ca2+ entry via orai1 induces podocyte actin remodeling and causes proteinuria
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bc2e1cc7ee1947fb859dbac6a5b38a43
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AT kyuheehwang insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT baotndang insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT minseobeom insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT indeokkong insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT yousanggwack insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT seyoungyu insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT heonyunggee insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT lutzbirnbaumer insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT kyusangpark insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
AT seungkuycha insulinactivatedstoreoperatedca2entryviaorai1inducespodocyteactinremodelingandcausesproteinuria
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