Emerging Roles of Pleckstrin-2 Beyond Cell Spreading

Pleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellu...

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Autores principales:	Gengchen Wang, Qian Zhou, Yan Xu, Baobing Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pleckstrin-2 cell spreading erythropoiesis metastasis tumorigenesis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bc303c5c7a1641348e37f00139b358dd
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id	oai:doaj.org-article:bc303c5c7a1641348e37f00139b358dd
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spelling	oai:doaj.org-article:bc303c5c7a1641348e37f00139b358dd2021-11-18T09:57:05ZEmerging Roles of Pleckstrin-2 Beyond Cell Spreading2296-634X10.3389/fcell.2021.768238https://doaj.org/article/bc303c5c7a1641348e37f00139b358dd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.768238/fullhttps://doaj.org/toc/2296-634XPleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellular events beyond cell spreading, such as erythropoiesis, tumorigenesis and metastasis. It serves as a potential diagnostic and prognostic biomarker as well as an attractive target for the treatment of cancers. Herein, we summary the protein structure and molecular interactions of pleckstrin-2, with an emphasis on its regulatory roles in tumorigenesis.Gengchen WangQian ZhouYan XuBaobing ZhaoBaobing ZhaoFrontiers Media S.A.articlepleckstrin-2cell spreadingerythropoiesismetastasistumorigenesisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pleckstrin-2 cell spreading erythropoiesis metastasis tumorigenesis Biology (General) QH301-705.5
spellingShingle	pleckstrin-2 cell spreading erythropoiesis metastasis tumorigenesis Biology (General) QH301-705.5 Gengchen Wang Qian Zhou Yan Xu Baobing Zhao Baobing Zhao Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
description	Pleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellular events beyond cell spreading, such as erythropoiesis, tumorigenesis and metastasis. It serves as a potential diagnostic and prognostic biomarker as well as an attractive target for the treatment of cancers. Herein, we summary the protein structure and molecular interactions of pleckstrin-2, with an emphasis on its regulatory roles in tumorigenesis.
format	article
author	Gengchen Wang Qian Zhou Yan Xu Baobing Zhao Baobing Zhao
author_facet	Gengchen Wang Qian Zhou Yan Xu Baobing Zhao Baobing Zhao
author_sort	Gengchen Wang
title	Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_short	Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_full	Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_fullStr	Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_full_unstemmed	Emerging Roles of Pleckstrin-2 Beyond Cell Spreading
title_sort	emerging roles of pleckstrin-2 beyond cell spreading
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bc303c5c7a1641348e37f00139b358dd
work_keys_str_mv	AT gengchenwang emergingrolesofpleckstrin2beyondcellspreading AT qianzhou emergingrolesofpleckstrin2beyondcellspreading AT yanxu emergingrolesofpleckstrin2beyondcellspreading AT baobingzhao emergingrolesofpleckstrin2beyondcellspreading AT baobingzhao emergingrolesofpleckstrin2beyondcellspreading
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Emerging Roles of Pleckstrin-2 Beyond Cell Spreading

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