Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease

Parkinson’s disease (PD) is one of the prevalent neurodegenerative diseases associated with preferential loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and accumulation of α-synuclein in DA neurons. Even though the precise pathogenesis of PD is not clear, a large number of...

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Autores principales:	Chao Gu, Yajing Chen, Yan Chen, Chun-Feng Liu, Zengyan Zhu, Mei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	G protein-coupled receptor (GPCR) microglial activation Parkinson’s disease neuroinflammation dopaminergic (DA) neuronal loss Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/bc31b713b58845c58efeb48c74bb5822
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spelling	oai:doaj.org-article:bc31b713b58845c58efeb48c74bb58222021-11-16T05:50:06ZRole of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease1663-436510.3389/fnagi.2021.768156https://doaj.org/article/bc31b713b58845c58efeb48c74bb58222021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.768156/fullhttps://doaj.org/toc/1663-4365Parkinson’s disease (PD) is one of the prevalent neurodegenerative diseases associated with preferential loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and accumulation of α-synuclein in DA neurons. Even though the precise pathogenesis of PD is not clear, a large number of studies have shown that microglia-mediated neuroinflammation plays a vital role in the process of PD development. G protein-coupled receptors (GPCRs) are widely expressed in microglia and several of them act as regulators of microglial activation upon corresponding ligands stimulations. Upon α-synuclein insults, microglia would become excessively activated through some innate immune receptors. Presently, as lack of ideal drugs for treating PD, certain GPCR which is highly expressed in microglia of PD brain and mediates neuroinflammation effectively could be a prospective source for PD therapeutic intervention. Here, six kinds of GPCRs and two types of innate immune receptors were introduced, containing adenosine receptors, purinergic receptors, metabotropic glutamate receptors, adrenergic receptors, cannabinoid receptors, and melatonin receptors and their roles in neuroinflammation; we highlighted the relationship between these six GPCRs and microglial activation in PD. Based on the existing findings, we tried to expound the implication of microglial GPCRs-regulated neuroinflammation to the pathophysiology of PD and their potential to become a new expectation for clinical therapeutics.Chao GuYajing ChenYan ChenChun-Feng LiuZengyan ZhuMei WangFrontiers Media S.A.articleG protein-coupled receptor (GPCR)microglial activationParkinson’s diseaseneuroinflammationdopaminergic (DA) neuronal lossNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	G protein-coupled receptor (GPCR) microglial activation Parkinson’s disease neuroinflammation dopaminergic (DA) neuronal loss Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	G protein-coupled receptor (GPCR) microglial activation Parkinson’s disease neuroinflammation dopaminergic (DA) neuronal loss Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Chao Gu Yajing Chen Yan Chen Chun-Feng Liu Zengyan Zhu Mei Wang Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
description	Parkinson’s disease (PD) is one of the prevalent neurodegenerative diseases associated with preferential loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and accumulation of α-synuclein in DA neurons. Even though the precise pathogenesis of PD is not clear, a large number of studies have shown that microglia-mediated neuroinflammation plays a vital role in the process of PD development. G protein-coupled receptors (GPCRs) are widely expressed in microglia and several of them act as regulators of microglial activation upon corresponding ligands stimulations. Upon α-synuclein insults, microglia would become excessively activated through some innate immune receptors. Presently, as lack of ideal drugs for treating PD, certain GPCR which is highly expressed in microglia of PD brain and mediates neuroinflammation effectively could be a prospective source for PD therapeutic intervention. Here, six kinds of GPCRs and two types of innate immune receptors were introduced, containing adenosine receptors, purinergic receptors, metabotropic glutamate receptors, adrenergic receptors, cannabinoid receptors, and melatonin receptors and their roles in neuroinflammation; we highlighted the relationship between these six GPCRs and microglial activation in PD. Based on the existing findings, we tried to expound the implication of microglial GPCRs-regulated neuroinflammation to the pathophysiology of PD and their potential to become a new expectation for clinical therapeutics.
format	article
author	Chao Gu Yajing Chen Yan Chen Chun-Feng Liu Zengyan Zhu Mei Wang
author_facet	Chao Gu Yajing Chen Yan Chen Chun-Feng Liu Zengyan Zhu Mei Wang
author_sort	Chao Gu
title	Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
title_short	Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
title_full	Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
title_fullStr	Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
title_full_unstemmed	Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
title_sort	role of g protein-coupled receptors in microglial activation: implication in parkinson’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bc31b713b58845c58efeb48c74bb5822
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Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease

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