Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles of several assembly factors, including GTPBP6’s ro...

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Autores principales:	Hauke S. Hillen, Elena Lavdovskaia, Franziska Nadler, Elisa Hanitsch, Andreas Linden, Katherine E. Bohnsack, Henning Urlaub, Ricarda Richter-Dennerlein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc353a11e2254ccf9d5c1524e48f6a3c
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spelling	oai:doaj.org-article:bc353a11e2254ccf9d5c1524e48f6a3c2021-12-02T16:04:21ZStructural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling10.1038/s41467-021-23702-y2041-1723https://doaj.org/article/bc353a11e2254ccf9d5c1524e48f6a3c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23702-yhttps://doaj.org/toc/2041-1723Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles of several assembly factors, including GTPBP6’s role in both ribosome biogenesis and recycling.Hauke S. HillenElena LavdovskaiaFranziska NadlerElisa HanitschAndreas LindenKatherine E. BohnsackHenning UrlaubRicarda Richter-DennerleinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hauke S. Hillen Elena Lavdovskaia Franziska Nadler Elisa Hanitsch Andreas Linden Katherine E. Bohnsack Henning Urlaub Ricarda Richter-Dennerlein Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
description	Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles of several assembly factors, including GTPBP6’s role in both ribosome biogenesis and recycling.
format	article
author	Hauke S. Hillen Elena Lavdovskaia Franziska Nadler Elisa Hanitsch Andreas Linden Katherine E. Bohnsack Henning Urlaub Ricarda Richter-Dennerlein
author_facet	Hauke S. Hillen Elena Lavdovskaia Franziska Nadler Elisa Hanitsch Andreas Linden Katherine E. Bohnsack Henning Urlaub Ricarda Richter-Dennerlein
author_sort	Hauke S. Hillen
title	Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
title_short	Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
title_full	Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
title_fullStr	Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
title_full_unstemmed	Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling
title_sort	structural basis of gtpase-mediated mitochondrial ribosome biogenesis and recycling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc353a11e2254ccf9d5c1524e48f6a3c
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Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

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