Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota

Abstract Malaria is an infectious disease responsible for the death of around 450,000 people annually. As an effective vaccine against the parasite that causes malaria is not available, antimalarial drug treatments are critical in fighting the disease. Previous data has shown that the gut microbiota...

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Autores principales:	Joshua E. Denny, Nathan W. Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc359a6f053b4c3e996dc7c8d2d32fea
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spelling	oai:doaj.org-article:bc359a6f053b4c3e996dc7c8d2d32fea2021-12-02T16:08:05ZOral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota10.1038/s41598-019-48454-02045-2322https://doaj.org/article/bc359a6f053b4c3e996dc7c8d2d32fea2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48454-0https://doaj.org/toc/2045-2322Abstract Malaria is an infectious disease responsible for the death of around 450,000 people annually. As an effective vaccine against the parasite that causes malaria is not available, antimalarial drug treatments are critical in fighting the disease. Previous data has shown that the gut microbiota is important in modulating the severity of malaria. Although it is well appreciated that antibiotics substantially alter the gut microbiota, it is largely unknown how antimalarial drugs impact the gut microbiota. We show here that the two commonly used artemisinin combination therapies of artesunate plus amodiaquine and artemether plus lumefantrine do not change the gut microbiota. The overall relative species abundance and alpha diversity remained stable after treatment, while beta diversity analysis showed minimal changes due to drug treatment, which were transient and quickly returned to baseline. Additionally, treatment with antimalarial drugs did not change the kinetics of later Plasmodium infection. Taken together, antimalarial drug administration does not affect the gut microbiota.Joshua E. DennyNathan W. SchmidtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joshua E. Denny Nathan W. Schmidt Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota
description	Abstract Malaria is an infectious disease responsible for the death of around 450,000 people annually. As an effective vaccine against the parasite that causes malaria is not available, antimalarial drug treatments are critical in fighting the disease. Previous data has shown that the gut microbiota is important in modulating the severity of malaria. Although it is well appreciated that antibiotics substantially alter the gut microbiota, it is largely unknown how antimalarial drugs impact the gut microbiota. We show here that the two commonly used artemisinin combination therapies of artesunate plus amodiaquine and artemether plus lumefantrine do not change the gut microbiota. The overall relative species abundance and alpha diversity remained stable after treatment, while beta diversity analysis showed minimal changes due to drug treatment, which were transient and quickly returned to baseline. Additionally, treatment with antimalarial drugs did not change the kinetics of later Plasmodium infection. Taken together, antimalarial drug administration does not affect the gut microbiota.
format	article
author	Joshua E. Denny Nathan W. Schmidt
author_facet	Joshua E. Denny Nathan W. Schmidt
author_sort	Joshua E. Denny
title	Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota
title_short	Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota
title_full	Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota
title_fullStr	Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota
title_full_unstemmed	Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota
title_sort	oral administration of clinically relevant antimalarial drugs does not modify the murine gut microbiota
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bc359a6f053b4c3e996dc7c8d2d32fea
work_keys_str_mv	AT joshuaedenny oraladministrationofclinicallyrelevantantimalarialdrugsdoesnotmodifythemurinegutmicrobiota AT nathanwschmidt oraladministrationofclinicallyrelevantantimalarialdrugsdoesnotmodifythemurinegutmicrobiota
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Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota

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