Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy

Abstract An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the e...

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Autores principales:	R. Bruch, C. Chatelle, A. Kling, B. Rebmann, S. Wirth, S. Schumann, W. Weber, C. Dincer, G. Urban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc35e50ee17a4018acd7b593716960cb
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spelling	oai:doaj.org-article:bc35e50ee17a4018acd7b593716960cb2021-12-02T15:05:09ZClinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy10.1038/s41598-017-03338-z2045-2322https://doaj.org/article/bc35e50ee17a4018acd7b593716960cb2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03338-zhttps://doaj.org/toc/2045-2322Abstract An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients’ outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy. Herein, we present a bioinspired approach for the bedside monitoring of free accessible ß-lactam antibiotics, including penicillins (piperacillin) and cephalosporins (cefuroxime and cefazolin) in untreated plasma samples. The introduced system combines a disposable microfluidic chip with a naturally occurring penicillin-binding protein, resulting in a high-performance platform, capable of gauging very low antibiotic concentrations (less than 6 ng ml−1) from only 1 µl of serum. The system’s applicability to a personalized antibiotherapy was successfully demonstrated by monitoring the pharmacokinetics of patients, treated with ß-lactam antibiotics, undergoing surgery.R. BruchC. ChatelleA. KlingB. RebmannS. WirthS. SchumannW. WeberC. DincerG. UrbanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q R. Bruch C. Chatelle A. Kling B. Rebmann S. Wirth S. Schumann W. Weber C. Dincer G. Urban Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
description	Abstract An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients’ outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy. Herein, we present a bioinspired approach for the bedside monitoring of free accessible ß-lactam antibiotics, including penicillins (piperacillin) and cephalosporins (cefuroxime and cefazolin) in untreated plasma samples. The introduced system combines a disposable microfluidic chip with a naturally occurring penicillin-binding protein, resulting in a high-performance platform, capable of gauging very low antibiotic concentrations (less than 6 ng ml−1) from only 1 µl of serum. The system’s applicability to a personalized antibiotherapy was successfully demonstrated by monitoring the pharmacokinetics of patients, treated with ß-lactam antibiotics, undergoing surgery.
format	article
author	R. Bruch C. Chatelle A. Kling B. Rebmann S. Wirth S. Schumann W. Weber C. Dincer G. Urban
author_facet	R. Bruch C. Chatelle A. Kling B. Rebmann S. Wirth S. Schumann W. Weber C. Dincer G. Urban
author_sort	R. Bruch
title	Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
title_short	Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
title_full	Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
title_fullStr	Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
title_full_unstemmed	Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
title_sort	clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bc35e50ee17a4018acd7b593716960cb
work_keys_str_mv	AT rbruch clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT cchatelle clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT akling clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT brebmann clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT swirth clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT sschumann clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT wweber clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT cdincer clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy AT gurban clinicalonsitemonitoringofßlactamantibioticsforapersonalizedantibiotherapy
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Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy

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