Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.

<h4>Background</h4>Genome reduction is a common evolutionary process affecting bacterial lineages that establish symbiotic or pathogenic associations with eukaryotic hosts. Such associations yield highly reduced genomes with greatly streamlined metabolic abilities shaped by the type of e...

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Autores principales:	Eugeni Belda, Francisco J Silva, Juli Peretó, Andrés Moya
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc37f466398f4f7dbd9741758ae62d9b
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spelling	oai:doaj.org-article:bc37f466398f4f7dbd9741758ae62d9b2021-11-18T07:29:27ZMetabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.1932-620310.1371/journal.pone.0030652https://doaj.org/article/bc37f466398f4f7dbd9741758ae62d9b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22292008/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Genome reduction is a common evolutionary process affecting bacterial lineages that establish symbiotic or pathogenic associations with eukaryotic hosts. Such associations yield highly reduced genomes with greatly streamlined metabolic abilities shaped by the type of ecological association with the host. Sodalis glossinidius, the secondary endosymbiont of tsetse flies, represents one of the few complete genomes available of a bacterium at the initial stages of this process. In the present study, genome reduction is studied from a systems biology perspective through the reconstruction and functional analysis of genome-scale metabolic networks of S. glossinidius.<h4>Results</h4>The functional profile of ancestral and extant metabolic networks sheds light on the evolutionary events underlying transition to a host-dependent lifestyle. Meanwhile, reductive evolution simulations on the extant metabolic network can predict possible future evolution of S. glossinidius in the context of genome reduction. Finally, knockout simulations in different metabolic systems reveal a gradual decrease in network robustness to different mutational events for bacterial endosymbionts at different stages of the symbiotic association.<h4>Conclusions</h4>Stoichiometric analysis reveals few gene inactivation events whose effects on the functionality of S. glossinidius metabolic systems are drastic enough to account for the ecological transition from a free-living to host-dependent lifestyle. The decrease in network robustness across different metabolic systems may be associated with the progressive integration in the more stable environment provided by the insect host. Finally, reductive evolution simulations reveal the strong influence that external conditions exert on the evolvability of metabolic systems.Eugeni BeldaFrancisco J SilvaJuli PeretóAndrés MoyaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30652 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eugeni Belda Francisco J Silva Juli Peretó Andrés Moya Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
description	<h4>Background</h4>Genome reduction is a common evolutionary process affecting bacterial lineages that establish symbiotic or pathogenic associations with eukaryotic hosts. Such associations yield highly reduced genomes with greatly streamlined metabolic abilities shaped by the type of ecological association with the host. Sodalis glossinidius, the secondary endosymbiont of tsetse flies, represents one of the few complete genomes available of a bacterium at the initial stages of this process. In the present study, genome reduction is studied from a systems biology perspective through the reconstruction and functional analysis of genome-scale metabolic networks of S. glossinidius.<h4>Results</h4>The functional profile of ancestral and extant metabolic networks sheds light on the evolutionary events underlying transition to a host-dependent lifestyle. Meanwhile, reductive evolution simulations on the extant metabolic network can predict possible future evolution of S. glossinidius in the context of genome reduction. Finally, knockout simulations in different metabolic systems reveal a gradual decrease in network robustness to different mutational events for bacterial endosymbionts at different stages of the symbiotic association.<h4>Conclusions</h4>Stoichiometric analysis reveals few gene inactivation events whose effects on the functionality of S. glossinidius metabolic systems are drastic enough to account for the ecological transition from a free-living to host-dependent lifestyle. The decrease in network robustness across different metabolic systems may be associated with the progressive integration in the more stable environment provided by the insect host. Finally, reductive evolution simulations reveal the strong influence that external conditions exert on the evolvability of metabolic systems.
format	article
author	Eugeni Belda Francisco J Silva Juli Peretó Andrés Moya
author_facet	Eugeni Belda Francisco J Silva Juli Peretó Andrés Moya
author_sort	Eugeni Belda
title	Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
title_short	Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
title_full	Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
title_fullStr	Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
title_full_unstemmed	Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.
title_sort	metabolic networks of sodalis glossinidius: a systems biology approach to reductive evolution.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bc37f466398f4f7dbd9741758ae62d9b
work_keys_str_mv	AT eugenibelda metabolicnetworksofsodalisglossinidiusasystemsbiologyapproachtoreductiveevolution AT franciscojsilva metabolicnetworksofsodalisglossinidiusasystemsbiologyapproachtoreductiveevolution AT julipereto metabolicnetworksofsodalisglossinidiusasystemsbiologyapproachtoreductiveevolution AT andresmoya metabolicnetworksofsodalisglossinidiusasystemsbiologyapproachtoreductiveevolution
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Metabolic networks of Sodalis glossinidius: a systems biology approach to reductive evolution.

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