Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
This study reports the role played by the mutation status of Uveal Melanoma (UM) in relation to hepatic metastatic patterns as seen on imaging modalities. Radiological images were obtained from 123 patients treated at the Erasmus Medical Center Rotterdam or the Rotterdam Eye Hospital. Radiological i...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/bc3b3d5de9d44426ab3c53d81f4cab6a |
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| Sumario: | This study reports the role played by the mutation status of Uveal Melanoma (UM) in relation to hepatic metastatic patterns as seen on imaging modalities. Radiological images were obtained from 123 patients treated at the Erasmus Medical Center Rotterdam or the Rotterdam Eye Hospital. Radiological images were derived from either computed tomography or magnetic resonance imaging. Hepatic metastatic patterns were classified by counting the number of metastases found in the liver. Miliary metastatic pattern (innumerable small metastases in the entire liver) was analyzed separately. Mutation status was determined in 85 patients. Median disease-free survival (DFS) and survival with metastases differed significantly between each of the metastatic patterns (respectively, <i>p</i> = 0.009, <i>p</i> < 0.001), both in favor of patients with less hepatic metastases. The mutation status of the primary tumor was not correlated with any hepatic tumor profiles (<i>p</i> = 0.296). Of the patients who had a solitary metastasis (<i>n</i> = 18), 11 originated from a primary <i>BAP1</i>-mutated tumors and one from a primary <i>SF3B1</i>-mutated tumor. Of the patients who had a miliary metastasis pattern (<i>n</i> = 24), 17 had a primary <i>BAP1</i>-mutated tumor and two had a primary <i>SF3B1</i>-mutated tumor. Chromosome 8p loss was significantly more in patients with more metastases (<i>p</i> = 0.045). Moreover, the primary UMs of patients with miliary metastases harbored more chromosome 8p and 1p loss, compared to patients with single solitary metastasis (<i>p</i> = 0.035 and <i>p</i> = 0.026, respectively). In conclusion, our study shows that there is an inverse correlation of the number of metastasis with the DFS and metastasized survival, indicating separate growth patterns. We also revealed that the number and type of metastases is irrelevant to the prognostic mutation status of the tumor, showing that both <i>BAP1</i>- and <i>SF3B1</i>-mutated UM can result in solitary and miliary metastases, indicating that other processes lay ground to the different metastatic patterns. |
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