Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status

This study reports the role played by the mutation status of Uveal Melanoma (UM) in relation to hepatic metastatic patterns as seen on imaging modalities. Radiological images were obtained from 123 patients treated at the Erasmus Medical Center Rotterdam or the Rotterdam Eye Hospital. Radiological i...

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Autores principales:	Serdar Yavuzyigitoglu, Michael C. Y. Tang, Miguel Jansen, Kaspar W. Geul, Roy S. Dwarkasing, Jolanda Vaarwater, Wojtek Drabarek, Robert M. Verdijk, Dion Paridaens, Nicole C. Naus, Erwin Brosens, Annelies de Klein, Emine Kilic
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	uveal melanoma choroidal melanoma eye melanoma BAP1 SF3B1 liver metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bc3b3d5de9d44426ab3c53d81f4cab6a
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spelling	oai:doaj.org-article:bc3b3d5de9d44426ab3c53d81f4cab6a2021-11-11T15:28:12ZRadiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status10.3390/cancers132153162072-6694https://doaj.org/article/bc3b3d5de9d44426ab3c53d81f4cab6a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5316https://doaj.org/toc/2072-6694This study reports the role played by the mutation status of Uveal Melanoma (UM) in relation to hepatic metastatic patterns as seen on imaging modalities. Radiological images were obtained from 123 patients treated at the Erasmus Medical Center Rotterdam or the Rotterdam Eye Hospital. Radiological images were derived from either computed tomography or magnetic resonance imaging. Hepatic metastatic patterns were classified by counting the number of metastases found in the liver. Miliary metastatic pattern (innumerable small metastases in the entire liver) was analyzed separately. Mutation status was determined in 85 patients. Median disease-free survival (DFS) and survival with metastases differed significantly between each of the metastatic patterns (respectively, <i>p</i> = 0.009, <i>p</i> < 0.001), both in favor of patients with less hepatic metastases. The mutation status of the primary tumor was not correlated with any hepatic tumor profiles (<i>p</i> = 0.296). Of the patients who had a solitary metastasis (<i>n</i> = 18), 11 originated from a primary <i>BAP1</i>-mutated tumors and one from a primary <i>SF3B1</i>-mutated tumor. Of the patients who had a miliary metastasis pattern (<i>n</i> = 24), 17 had a primary <i>BAP1</i>-mutated tumor and two had a primary <i>SF3B1</i>-mutated tumor. Chromosome 8p loss was significantly more in patients with more metastases (<i>p</i> = 0.045). Moreover, the primary UMs of patients with miliary metastases harbored more chromosome 8p and 1p loss, compared to patients with single solitary metastasis (<i>p</i> = 0.035 and <i>p</i> = 0.026, respectively). In conclusion, our study shows that there is an inverse correlation of the number of metastasis with the DFS and metastasized survival, indicating separate growth patterns. We also revealed that the number and type of metastases is irrelevant to the prognostic mutation status of the tumor, showing that both <i>BAP1</i>- and <i>SF3B1</i>-mutated UM can result in solitary and miliary metastases, indicating that other processes lay ground to the different metastatic patterns.Serdar YavuzyigitogluMichael C. Y. TangMiguel JansenKaspar W. GeulRoy S. DwarkasingJolanda VaarwaterWojtek DrabarekRobert M. VerdijkDion ParidaensNicole C. NausErwin BrosensAnnelies de KleinEmine KilicMDPI AGarticleuveal melanomachoroidal melanomaeye melanomaBAP1SF3B1liver metastasesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5316, p 5316 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal melanoma choroidal melanoma eye melanoma BAP1 SF3B1 liver metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	uveal melanoma choroidal melanoma eye melanoma BAP1 SF3B1 liver metastases Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Serdar Yavuzyigitoglu Michael C. Y. Tang Miguel Jansen Kaspar W. Geul Roy S. Dwarkasing Jolanda Vaarwater Wojtek Drabarek Robert M. Verdijk Dion Paridaens Nicole C. Naus Erwin Brosens Annelies de Klein Emine Kilic Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
description	This study reports the role played by the mutation status of Uveal Melanoma (UM) in relation to hepatic metastatic patterns as seen on imaging modalities. Radiological images were obtained from 123 patients treated at the Erasmus Medical Center Rotterdam or the Rotterdam Eye Hospital. Radiological images were derived from either computed tomography or magnetic resonance imaging. Hepatic metastatic patterns were classified by counting the number of metastases found in the liver. Miliary metastatic pattern (innumerable small metastases in the entire liver) was analyzed separately. Mutation status was determined in 85 patients. Median disease-free survival (DFS) and survival with metastases differed significantly between each of the metastatic patterns (respectively, <i>p</i> = 0.009, <i>p</i> < 0.001), both in favor of patients with less hepatic metastases. The mutation status of the primary tumor was not correlated with any hepatic tumor profiles (<i>p</i> = 0.296). Of the patients who had a solitary metastasis (<i>n</i> = 18), 11 originated from a primary <i>BAP1</i>-mutated tumors and one from a primary <i>SF3B1</i>-mutated tumor. Of the patients who had a miliary metastasis pattern (<i>n</i> = 24), 17 had a primary <i>BAP1</i>-mutated tumor and two had a primary <i>SF3B1</i>-mutated tumor. Chromosome 8p loss was significantly more in patients with more metastases (<i>p</i> = 0.045). Moreover, the primary UMs of patients with miliary metastases harbored more chromosome 8p and 1p loss, compared to patients with single solitary metastasis (<i>p</i> = 0.035 and <i>p</i> = 0.026, respectively). In conclusion, our study shows that there is an inverse correlation of the number of metastasis with the DFS and metastasized survival, indicating separate growth patterns. We also revealed that the number and type of metastases is irrelevant to the prognostic mutation status of the tumor, showing that both <i>BAP1</i>- and <i>SF3B1</i>-mutated UM can result in solitary and miliary metastases, indicating that other processes lay ground to the different metastatic patterns.
format	article
author	Serdar Yavuzyigitoglu Michael C. Y. Tang Miguel Jansen Kaspar W. Geul Roy S. Dwarkasing Jolanda Vaarwater Wojtek Drabarek Robert M. Verdijk Dion Paridaens Nicole C. Naus Erwin Brosens Annelies de Klein Emine Kilic
author_facet	Serdar Yavuzyigitoglu Michael C. Y. Tang Miguel Jansen Kaspar W. Geul Roy S. Dwarkasing Jolanda Vaarwater Wojtek Drabarek Robert M. Verdijk Dion Paridaens Nicole C. Naus Erwin Brosens Annelies de Klein Emine Kilic
author_sort	Serdar Yavuzyigitoglu
title	Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
title_short	Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
title_full	Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
title_fullStr	Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
title_full_unstemmed	Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status
title_sort	radiological patterns of uveal melanoma liver metastases in correlation to genetic status
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bc3b3d5de9d44426ab3c53d81f4cab6a
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Radiological Patterns of Uveal Melanoma Liver Metastases in Correlation to Genetic Status

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