The autophagy protein ATG9A enables lipid mobilization from lipid droplets
ATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty acid import and β-oxidation.
Enregistré dans:
Auteurs principaux: | Elodie Mailler, Carlos M. Guardia, Xiaofei Bai, Michal Jarnik, Chad D. Williamson, Yan Li, Nunziata Maio, Andy Golden, Juan S. Bonifacino |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/bc3b482686c54ef6a34fb727e681922d |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Author Correction: In vitro inhibition of hepatic stellate cell activation by the autophagy-related lipid droplet protein ATG2A
par: Yun Hong, et autres
Publié: (2018) -
Triglyceride blisters in lipid bilayers: implications for lipid droplet biogenesis and the mobile lipid signal in cancer cell membranes.
par: Himanshu Khandelia, et autres
Publié: (2010) -
Lipid droplet and peroxisome biogenesis occur at the same ER subdomains
par: Amit S. Joshi, et autres
Publié: (2018) -
A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
par: Yi-Tong Li, et autres
Publié: (2017) -
Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
par: Yuta Ogasawara, et autres
Publié: (2020)