Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis

The creation of new bonds via C-F bond cleavage of readily available per- or oligofluorinated compounds has received growing interest. Using such a strategy, a myriad of valuable partially fluorinated products can be prepared, which otherwise are difficult to make by the conventional C-F bond format...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Lei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	visible light radical C-F bond cleavage photoredox Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/bc3c13fd728845c3af7dbafb5a1b209d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc3c13fd728845c3af7dbafb5a1b209d
record_format	dspace
spelling	oai:doaj.org-article:bc3c13fd728845c3af7dbafb5a1b209d2021-11-25T18:29:27ZRecent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis10.3390/molecules262270511420-3049https://doaj.org/article/bc3c13fd728845c3af7dbafb5a1b209d2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/7051https://doaj.org/toc/1420-3049The creation of new bonds via C-F bond cleavage of readily available per- or oligofluorinated compounds has received growing interest. Using such a strategy, a myriad of valuable partially fluorinated products can be prepared, which otherwise are difficult to make by the conventional C-F bond formation methods. Visible light photoredox catalysis has been proven as an important and powerful tool for defluorinative reactions due to its mild, easy to handle, and environmentally benign characteristics. Compared to the classical C-F activation that proceeds via two-electron processes, radicals are the key intermediates using visible light photoredox catalysis, providing new modes for the cleavage of C-F bonds. In this review, a summary of the visible light-promoted C-F bond cleavage since 2018 was presented. The contents were classified by the fluorosubstrates, including polyfluorinated arenes, <i>gem</i>-difluoroalkenes, trifluoromethyl arenes, and trifluoromethyl alkenes. An emphasis is placed on the discussion of the mechanisms and limitations of these reactions. Finally, my personal perspective on the future development of this rapidly emerging field was provided.Lei ZhouMDPI AGarticlevisible lightradicalC-F bondcleavagephotoredoxOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 7051, p 7051 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	visible light radical C-F bond cleavage photoredox Organic chemistry QD241-441
spellingShingle	visible light radical C-F bond cleavage photoredox Organic chemistry QD241-441 Lei Zhou Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis
description	The creation of new bonds via C-F bond cleavage of readily available per- or oligofluorinated compounds has received growing interest. Using such a strategy, a myriad of valuable partially fluorinated products can be prepared, which otherwise are difficult to make by the conventional C-F bond formation methods. Visible light photoredox catalysis has been proven as an important and powerful tool for defluorinative reactions due to its mild, easy to handle, and environmentally benign characteristics. Compared to the classical C-F activation that proceeds via two-electron processes, radicals are the key intermediates using visible light photoredox catalysis, providing new modes for the cleavage of C-F bonds. In this review, a summary of the visible light-promoted C-F bond cleavage since 2018 was presented. The contents were classified by the fluorosubstrates, including polyfluorinated arenes, <i>gem</i>-difluoroalkenes, trifluoromethyl arenes, and trifluoromethyl alkenes. An emphasis is placed on the discussion of the mechanisms and limitations of these reactions. Finally, my personal perspective on the future development of this rapidly emerging field was provided.
format	article
author	Lei Zhou
author_facet	Lei Zhou
author_sort	Lei Zhou
title	Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis
title_short	Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis
title_full	Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis
title_fullStr	Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis
title_full_unstemmed	Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis
title_sort	recent advances in c-f bond cleavage enabled by visible light photoredox catalysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bc3c13fd728845c3af7dbafb5a1b209d
work_keys_str_mv	AT leizhou recentadvancesincfbondcleavageenabledbyvisiblelightphotoredoxcatalysis
_version_	1718411101571383296

Recent Advances in C-F Bond Cleavage Enabled by Visible Light Photoredox Catalysis

Ejemplares similares