Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription

ABSTRACT Human papillomaviruses (HPV) are causative agents in 5% of all cancers, including the majority of anogenital and oropharyngeal cancers. Downregulation of innate immune genes (IIGs) by HPV to promote the viral life cycle is well documented; E6 and E7 are known repressors of these genes. More...

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Bibliographic Details
Main Authors: Claire D. James, Christian T. Fontan, Raymonde Otoa, Dipon Das, Apurva T. Prabhakar, Xu Wang, Molly L. Bristol, Iain M. Morgan
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
E6
E7
Online Access:https://doaj.org/article/bc3fbafcef0743e69b094470b763b5c5
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