Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the immune landscape in patients with glioblastoma foll...

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Autores principales:	Alexander H. Lee, Lu Sun, Aaron Y. Mochizuki, Jeremy G. Reynoso, Joey Orpilla, Frances Chow, Jenny C. Kienzler, Richard G. Everson, David A. Nathanson, Steven J. Bensinger, Linda M. Liau, Timothy Cloughesy, Willy Hugo, Robert M. Prins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc4276916a1e42c19b71f6a03a3eba26
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spelling	oai:doaj.org-article:bc4276916a1e42c19b71f6a03a3eba262021-11-28T12:32:37ZNeoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma10.1038/s41467-021-26940-22041-1723https://doaj.org/article/bc4276916a1e42c19b71f6a03a3eba262021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26940-2https://doaj.org/toc/2041-1723Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the immune landscape in patients with glioblastoma following neoadjuvant PD-1 checkpoint blockade.Alexander H. LeeLu SunAaron Y. MochizukiJeremy G. ReynosoJoey OrpillaFrances ChowJenny C. KienzlerRichard G. EversonDavid A. NathansonSteven J. BensingerLinda M. LiauTimothy CloughesyWilly HugoRobert M. PrinsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander H. Lee Lu Sun Aaron Y. Mochizuki Jeremy G. Reynoso Joey Orpilla Frances Chow Jenny C. Kienzler Richard G. Everson David A. Nathanson Steven J. Bensinger Linda M. Liau Timothy Cloughesy Willy Hugo Robert M. Prins Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
description	Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the immune landscape in patients with glioblastoma following neoadjuvant PD-1 checkpoint blockade.
format	article
author	Alexander H. Lee Lu Sun Aaron Y. Mochizuki Jeremy G. Reynoso Joey Orpilla Frances Chow Jenny C. Kienzler Richard G. Everson David A. Nathanson Steven J. Bensinger Linda M. Liau Timothy Cloughesy Willy Hugo Robert M. Prins
author_facet	Alexander H. Lee Lu Sun Aaron Y. Mochizuki Jeremy G. Reynoso Joey Orpilla Frances Chow Jenny C. Kienzler Richard G. Everson David A. Nathanson Steven J. Bensinger Linda M. Liau Timothy Cloughesy Willy Hugo Robert M. Prins
author_sort	Alexander H. Lee
title	Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
title_short	Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
title_full	Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
title_fullStr	Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
title_full_unstemmed	Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
title_sort	neoadjuvant pd-1 blockade induces t cell and cdc1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc4276916a1e42c19b71f6a03a3eba26
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Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma

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