Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ

Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ

ABSTRACT Emerging evidence indicates that human cytomegalovirus (HCMV) manipulates host cell signaling pathways using both proteins and noncoding RNAs. Several studies have shown that HCMV induces NF-κB signaling early in infection, resulting in the induction of antiviral proinflammatory cytokines w...

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Autores principales: Meaghan H. Hancock, Lauren M. Hook, Jennifer Mitchell, Jay A. Nelson
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/bc4277620a9546ccad70a6b7949f0798
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