A summary overview of the new, direct, target-specific oral anticoagulants

In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC) or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some definite advantages and disadvantages th...

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Autor principal:	G. L. Muntingh
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2016
Materias:	oral anticoagulants target-specific mechanism clinical pharmacokinetics Medicine R
Acceso en línea:	https://doaj.org/article/bc46706e7b02461ebd810a723ca70cc8
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spelling	oai:doaj.org-article:bc46706e7b02461ebd810a723ca70cc82021-11-24T07:44:18ZA summary overview of the new, direct, target-specific oral anticoagulants2078-61902078-620410.4102/safp.v58i4.4508https://doaj.org/article/bc46706e7b02461ebd810a723ca70cc82016-08-01T00:00:00Zhttps://safpj.co.za/index.php/safpj/article/view/4508https://doaj.org/toc/2078-6190https://doaj.org/toc/2078-6204In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC) or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some definite advantages and disadvantages that should be clear to physicians before prescribing any of them for patients. Many clinical trials have provided definitive information about the efficacy and safety of DOACs, yet many physicians remain sceptical about prescribing these drugs due to lack of answers to real world questions. The concerns are directed towards appropriate patient selection (the choice should be made according to age, renal function, compliance, cost, clinical condition, intake of other drugs), the mechanism of switching between agents, how these drugs affect routine laboratory tests and when monitoring is needed. Knowledge of other drugs that interact with the DOAC and management of severe bleeding will be reviewed and recommendations will be given to all of these concerns.G. L. MuntinghAOSISarticleoral anticoagulantstarget-specificmechanismclinicalpharmacokineticsMedicineRENSouth African Family Practice, Vol 58, Iss 4, Pp 22-25 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral anticoagulants target-specific mechanism clinical pharmacokinetics Medicine R
spellingShingle	oral anticoagulants target-specific mechanism clinical pharmacokinetics Medicine R G. L. Muntingh A summary overview of the new, direct, target-specific oral anticoagulants
description	In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC) or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some definite advantages and disadvantages that should be clear to physicians before prescribing any of them for patients. Many clinical trials have provided definitive information about the efficacy and safety of DOACs, yet many physicians remain sceptical about prescribing these drugs due to lack of answers to real world questions. The concerns are directed towards appropriate patient selection (the choice should be made according to age, renal function, compliance, cost, clinical condition, intake of other drugs), the mechanism of switching between agents, how these drugs affect routine laboratory tests and when monitoring is needed. Knowledge of other drugs that interact with the DOAC and management of severe bleeding will be reviewed and recommendations will be given to all of these concerns.
format	article
author	G. L. Muntingh
author_facet	G. L. Muntingh
author_sort	G. L. Muntingh
title	A summary overview of the new, direct, target-specific oral anticoagulants
title_short	A summary overview of the new, direct, target-specific oral anticoagulants
title_full	A summary overview of the new, direct, target-specific oral anticoagulants
title_fullStr	A summary overview of the new, direct, target-specific oral anticoagulants
title_full_unstemmed	A summary overview of the new, direct, target-specific oral anticoagulants
title_sort	summary overview of the new, direct, target-specific oral anticoagulants
publisher	AOSIS
publishDate	2016
url	https://doaj.org/article/bc46706e7b02461ebd810a723ca70cc8
work_keys_str_mv	AT glmuntingh asummaryoverviewofthenewdirecttargetspecificoralanticoagulants AT glmuntingh summaryoverviewofthenewdirecttargetspecificoralanticoagulants
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A summary overview of the new, direct, target-specific oral anticoagulants

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