Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery

Background: The efficacy of the treatment of type 1 diabetes can be markedly improved using artificial pancreas (AP), which is a technology to automatically control blood glucose levels. Aim: In this paper, we propose the construction of a controller for controlling the automated delivery of insuli...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vladimir A. Karpelyev, Yury I. Philippov, Artem V. Averin, Maxim D. Boyarsky, Dmitriy A. Gavrilov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	аrtificial pancreas intraperitoneal insulin infusion in silico control algorithm insulin pump preclinical studies Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/bc4e861935e44709905fd92bbd72ef64
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bc4e861935e44709905fd92bbd72ef64
record_format	dspace
spelling	oai:doaj.org-article:bc4e861935e44709905fd92bbd72ef642021-11-14T09:00:21ZDevelopment and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery2072-03512072-037810.14341/DM8265https://doaj.org/article/bc4e861935e44709905fd92bbd72ef642018-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8265https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background: The efficacy of the treatment of type 1 diabetes can be markedly improved using artificial pancreas (AP), which is a technology to automatically control blood glucose levels. Aim: In this paper, we propose the construction of a controller for controlling the automated delivery of insulin in AP based on a proportional–integral–derivative (PID) algorithm using intraperitoneal (IP) insulin delivery. Methods: The project used rapid-acting insulin in the IP space when setting up a PID controller with feedback to ensure the safe and efficient delivery of insulin. The controller was configured to satisfy feedback insulin present in blood. Controller check was performed In Silico using the metabolic simulator UVA\|Padova T1DMS on 10 virtual patients. Results: The proposed controller design has time to reach 83% within the glycaemic range of 70–140 mg/dl (3.9–7.8 mmol/l), without time spent in hypoglycaemia. Conclusions: In a future study we plan to test this controller in vivo to evaluate its performance in vivo.Vladimir A. KarpelyevYury I. PhilippovArtem V. AverinMaxim D. BoyarskyDmitriy A. GavrilovEndocrinology Research Centrearticleаrtificial pancreasintraperitoneal insulin infusionin silicocontrol algorithminsulin pumppreclinical studiesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 1, Pp 58-65 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	аrtificial pancreas intraperitoneal insulin infusion in silico control algorithm insulin pump preclinical studies Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	аrtificial pancreas intraperitoneal insulin infusion in silico control algorithm insulin pump preclinical studies Nutritional diseases. Deficiency diseases RC620-627 Vladimir A. Karpelyev Yury I. Philippov Artem V. Averin Maxim D. Boyarsky Dmitriy A. Gavrilov Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery
description	Background: The efficacy of the treatment of type 1 diabetes can be markedly improved using artificial pancreas (AP), which is a technology to automatically control blood glucose levels. Aim: In this paper, we propose the construction of a controller for controlling the automated delivery of insulin in AP based on a proportional–integral–derivative (PID) algorithm using intraperitoneal (IP) insulin delivery. Methods: The project used rapid-acting insulin in the IP space when setting up a PID controller with feedback to ensure the safe and efficient delivery of insulin. The controller was configured to satisfy feedback insulin present in blood. Controller check was performed In Silico using the metabolic simulator UVA\|Padova T1DMS on 10 virtual patients. Results: The proposed controller design has time to reach 83% within the glycaemic range of 70–140 mg/dl (3.9–7.8 mmol/l), without time spent in hypoglycaemia. Conclusions: In a future study we plan to test this controller in vivo to evaluate its performance in vivo.
format	article
author	Vladimir A. Karpelyev Yury I. Philippov Artem V. Averin Maxim D. Boyarsky Dmitriy A. Gavrilov
author_facet	Vladimir A. Karpelyev Yury I. Philippov Artem V. Averin Maxim D. Boyarsky Dmitriy A. Gavrilov
author_sort	Vladimir A. Karpelyev
title	Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery
title_short	Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery
title_full	Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery
title_fullStr	Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery
title_full_unstemmed	Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery
title_sort	development and in silico validation of the pid-algorithm for the artificial pancreas with intraperitoneal insulin delivery
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/bc4e861935e44709905fd92bbd72ef64
work_keys_str_mv	AT vladimirakarpelyev developmentandinsilicovalidationofthepidalgorithmfortheartificialpancreaswithintraperitonealinsulindelivery AT yuryiphilippov developmentandinsilicovalidationofthepidalgorithmfortheartificialpancreaswithintraperitonealinsulindelivery AT artemvaverin developmentandinsilicovalidationofthepidalgorithmfortheartificialpancreaswithintraperitonealinsulindelivery AT maximdboyarsky developmentandinsilicovalidationofthepidalgorithmfortheartificialpancreaswithintraperitonealinsulindelivery AT dmitriyagavrilov developmentandinsilicovalidationofthepidalgorithmfortheartificialpancreaswithintraperitonealinsulindelivery
_version_	1718429553883348992

Development and in silico validation of the PID-algorithm for the artificial pancreas with intraperitoneal insulin delivery

Ejemplares similares