Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To perform this study the livers of 23 dogs of different breed and sex were used. The tissue sections were stained with hematoxylin–eosin, and...

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Autores principales:	Jaber Jose Raduan, Velázquez-Wallraf Alicia S, Farray David, Ravelo-García Antonio G., Carrascosa Conrado, Rodríguez-Ventura Myriam, Perez Jose
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	liver hepatitis immunohistochemistry dog Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/bc5010c490ab4130aec3c055d2749417
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spelling	oai:doaj.org-article:bc5010c490ab4130aec3c055d27494172021-11-17T21:27:53ZImmunological and pathological investigations of non-specific reactive hepatitis in shelter dogs1820-744810.2478/acve-2019-0004https://doaj.org/article/bc5010c490ab4130aec3c055d27494172019-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2019-0004https://doaj.org/toc/1820-7448The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To perform this study the livers of 23 dogs of different breed and sex were used. The tissue sections were stained with hematoxylin–eosin, and immunohistochemically. The results of this work showed that NSRH was characterized by the infiltration of lymphocytes and plasma cells scattered throughout the liver parenchyma and in the portal stroma, and associated with inflammatory and non-inflammatory diseases in other organ systems. The inflammatory infiltrate of NSRH was composed of CD3+ T lymphocytes and HLA-DR+ lymphocytes, as well as IgG+ plasma cells and alpha-1-antitrypsin+ macrophages in the portal spaces and hepatic sinusoids.Jaber Jose RaduanVelázquez-Wallraf Alicia SFarray DavidRavelo-García Antonio G.Carrascosa ConradoRodríguez-Ventura MyriamPerez JoseSciendoarticleliverhepatitisimmunohistochemistrydogVeterinary medicineSF600-1100ENActa Veterinaria, Vol 69, Iss 1, Pp 61-72 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	liver hepatitis immunohistochemistry dog Veterinary medicine SF600-1100
spellingShingle	liver hepatitis immunohistochemistry dog Veterinary medicine SF600-1100 Jaber Jose Raduan Velázquez-Wallraf Alicia S Farray David Ravelo-García Antonio G. Carrascosa Conrado Rodríguez-Ventura Myriam Perez Jose Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
description	The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To perform this study the livers of 23 dogs of different breed and sex were used. The tissue sections were stained with hematoxylin–eosin, and immunohistochemically. The results of this work showed that NSRH was characterized by the infiltration of lymphocytes and plasma cells scattered throughout the liver parenchyma and in the portal stroma, and associated with inflammatory and non-inflammatory diseases in other organ systems. The inflammatory infiltrate of NSRH was composed of CD3+ T lymphocytes and HLA-DR+ lymphocytes, as well as IgG+ plasma cells and alpha-1-antitrypsin+ macrophages in the portal spaces and hepatic sinusoids.
format	article
author	Jaber Jose Raduan Velázquez-Wallraf Alicia S Farray David Ravelo-García Antonio G. Carrascosa Conrado Rodríguez-Ventura Myriam Perez Jose
author_facet	Jaber Jose Raduan Velázquez-Wallraf Alicia S Farray David Ravelo-García Antonio G. Carrascosa Conrado Rodríguez-Ventura Myriam Perez Jose
author_sort	Jaber Jose Raduan
title	Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
title_short	Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
title_full	Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
title_fullStr	Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
title_full_unstemmed	Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
title_sort	immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/bc5010c490ab4130aec3c055d2749417
work_keys_str_mv	AT jaberjoseraduan immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs AT velazquezwallrafalicias immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs AT farraydavid immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs AT ravelogarciaantoniog immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs AT carrascosaconrado immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs AT rodriguezventuramyriam immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs AT perezjose immunologicalandpathologicalinvestigationsofnonspecificreactivehepatitisinshelterdogs
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Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

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