Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis

Introduction: Diabetes mellitus is a chronic metabolic disorder that induces elevated plasma glucose levels. Diabetic patients are more susceptible to infections, especially fungal infections. There is a direct relationship between increased blood glucose levels and the number of Candida hyphae in t...

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Autores principales:	Alberto Rodríguez-Archilla, Claudia Piedra-Rosales
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2021
Materias:	blood glucose oral candidiasis diabetes mellitus risk factors Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bc503fb7a6dd4f27afca14aee5608c18
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spelling	oai:doaj.org-article:bc503fb7a6dd4f27afca14aee5608c182021-12-02T18:12:18ZCandida species oral detection and infection in patients with diabetes mellitus: a meta-analysis10.5281/zenodo.44952862695-5075https://doaj.org/article/bc503fb7a6dd4f27afca14aee5608c182021-02-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4495286https://doaj.org/toc/2695-5075Introduction: Diabetes mellitus is a chronic metabolic disorder that induces elevated plasma glucose levels. Diabetic patients are more susceptible to infections, especially fungal infections. There is a direct relationship between increased blood glucose levels and the number of Candida hyphae in the oral mucosa. This study aimed to evaluate oral candidiasis and the different Candida species found in patients with and without diabetes mellitus. Methods: A search for studies on oral candidiasis and diabetes mellitus was carried out in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS) and Google Scholar. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using the Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: 25 studies were included in this meta-analysis. Diabetes Mellitus patients tripled the probability of being infected by Candida species (OR:3.16, p<0.001). Likewise, Candida species infections were more likely in patients with poor glycemic control (OR:2.94, p<0.001) and with dentures (OR:2.22, p<0.001). In contrast, neither gender nor diabetes mellitus type of diabetes conditioned fungal infections (p>0.05). The most prevalent Candida species in both diabetics and controls were C. albicans and C. tropicalis. Diabetics had significantly fewer C. non-albicans species oral infections than non-diabetics (p=0.04). Conclusions: Diabetics are more prone to oral candidiasis, especially C. albicans infections.Alberto Rodríguez-ArchillaClaudia Piedra-RosalesEmergency Department of Hospital San Pedro (Logroño, Spain)articleblood glucoseoral candidiasisdiabetes mellitusrisk factorsMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 2, Pp 115-121 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood glucose oral candidiasis diabetes mellitus risk factors Medicine (General) R5-920
spellingShingle	blood glucose oral candidiasis diabetes mellitus risk factors Medicine (General) R5-920 Alberto Rodríguez-Archilla Claudia Piedra-Rosales Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
description	Introduction: Diabetes mellitus is a chronic metabolic disorder that induces elevated plasma glucose levels. Diabetic patients are more susceptible to infections, especially fungal infections. There is a direct relationship between increased blood glucose levels and the number of Candida hyphae in the oral mucosa. This study aimed to evaluate oral candidiasis and the different Candida species found in patients with and without diabetes mellitus. Methods: A search for studies on oral candidiasis and diabetes mellitus was carried out in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS) and Google Scholar. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using the Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: 25 studies were included in this meta-analysis. Diabetes Mellitus patients tripled the probability of being infected by Candida species (OR:3.16, p<0.001). Likewise, Candida species infections were more likely in patients with poor glycemic control (OR:2.94, p<0.001) and with dentures (OR:2.22, p<0.001). In contrast, neither gender nor diabetes mellitus type of diabetes conditioned fungal infections (p>0.05). The most prevalent Candida species in both diabetics and controls were C. albicans and C. tropicalis. Diabetics had significantly fewer C. non-albicans species oral infections than non-diabetics (p=0.04). Conclusions: Diabetics are more prone to oral candidiasis, especially C. albicans infections.
format	article
author	Alberto Rodríguez-Archilla Claudia Piedra-Rosales
author_facet	Alberto Rodríguez-Archilla Claudia Piedra-Rosales
author_sort	Alberto Rodríguez-Archilla
title	Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
title_short	Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
title_full	Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
title_fullStr	Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
title_full_unstemmed	Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
title_sort	candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2021
url	https://doaj.org/article/bc503fb7a6dd4f27afca14aee5608c18
work_keys_str_mv	AT albertorodriguezarchilla candidaspeciesoraldetectionandinfectioninpatientswithdiabetesmellitusametaanalysis AT claudiapiedrarosales candidaspeciesoraldetectionandinfectioninpatientswithdiabetesmellitusametaanalysis
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Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis

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