Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.

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Autores principales:	Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8
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spelling	oai:doaj.org-article:bc506b655aa8451493a382dfb1dd1fe82021-12-02T14:35:55ZAkt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation10.1038/s41467-019-10023-42041-1723https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe82019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10023-4https://doaj.org/toc/2041-1723T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.Nicholas JonesEmma E. VincentJames G. CroninSilvia PanettiMegan ChambersSean R. HolmSian E. OwensNigel J. FrancisDavid K. FinlayCatherine A. ThorntonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas Jones Emma E. Vincent James G. Cronin Silvia Panetti Megan Chambers Sean R. Holm Sian E. Owens Nigel J. Francis David K. Finlay Catherine A. Thornton Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
description	T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.
format	article
author	Nicholas Jones Emma E. Vincent James G. Cronin Silvia Panetti Megan Chambers Sean R. Holm Sian E. Owens Nigel J. Francis David K. Finlay Catherine A. Thornton
author_facet	Nicholas Jones Emma E. Vincent James G. Cronin Silvia Panetti Megan Chambers Sean R. Holm Sian E. Owens Nigel J. Francis David K. Finlay Catherine A. Thornton
author_sort	Nicholas Jones
title	Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
title_short	Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
title_full	Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
title_fullStr	Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
title_full_unstemmed	Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
title_sort	akt and stat5 mediate naïve human cd4+ t-cell early metabolic response to tcr stimulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8
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Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

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