Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection
ABSTRACT Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a mouse model of cryptococcal infection, we investigate...
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Auteurs principaux: | Jintao Xu, Alison J. Eastman, Adam Flaczyk, Lori M. Neal, Guolei Zhao, Jacob Carolan, Antoni N. Malachowski, Valerie R. Stolberg, Mohammed Yosri, Stephen W. Chensue, Jeffrey L. Curtis, John J. Osterholzer, Michal A. Olszewski |
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Format: | article |
Langue: | EN |
Publié: |
American Society for Microbiology
2016
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Accès en ligne: | https://doaj.org/article/bc50d61b42f745fba1b55ad5c2d86803 |
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