Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection

Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection

ABSTRACT Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a mouse model of cryptococcal infection, we investigate...

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Auteurs principaux: Jintao Xu, Alison J. Eastman, Adam Flaczyk, Lori M. Neal, Guolei Zhao, Jacob Carolan, Antoni N. Malachowski, Valerie R. Stolberg, Mohammed Yosri, Stephen W. Chensue, Jeffrey L. Curtis, John J. Osterholzer, Michal A. Olszewski
Format: article
Langue:EN
Publié: American Society for Microbiology 2016
Sujets:
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/bc50d61b42f745fba1b55ad5c2d86803
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https://doaj.org/article/bc50d61b42f745fba1b55ad5c2d86803

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