Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses

African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vacci...

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Autores principales:	Jose A. Barasona, Estefanía Cadenas-Fernández, Aleksandra Kosowska, Sandra Barroso-Arévalo, Belén Rivera, Rocío Sánchez, Néstor Porras, Carmina Gallardo, Jose M. Sánchez-Vizcaíno
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	African swine fever virus vaccine safety studies wild boar control disease Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bc5201d121a34e75a0698ec347093055
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spelling	oai:doaj.org-article:bc5201d121a34e75a0698ec3470930552021-12-01T16:54:20ZSafety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses1664-322410.3389/fimmu.2021.761753https://doaj.org/article/bc5201d121a34e75a0698ec3470930552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.761753/fullhttps://doaj.org/toc/1664-3224African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed.Jose A. BarasonaJose A. BarasonaEstefanía Cadenas-FernándezEstefanía Cadenas-FernándezAleksandra KosowskaAleksandra KosowskaSandra Barroso-ArévaloSandra Barroso-ArévaloBelén RiveraBelén RiveraRocío SánchezRocío SánchezNéstor PorrasCarmina GallardoJose M. Sánchez-VizcaínoJose M. Sánchez-VizcaínoFrontiers Media S.A.articleAfrican swine fevervirusvaccinesafety studieswild boarcontrol diseaseImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	African swine fever virus vaccine safety studies wild boar control disease Immunologic diseases. Allergy RC581-607
spellingShingle	African swine fever virus vaccine safety studies wild boar control disease Immunologic diseases. Allergy RC581-607 Jose A. Barasona Jose A. Barasona Estefanía Cadenas-Fernández Estefanía Cadenas-Fernández Aleksandra Kosowska Aleksandra Kosowska Sandra Barroso-Arévalo Sandra Barroso-Arévalo Belén Rivera Belén Rivera Rocío Sánchez Rocío Sánchez Néstor Porras Carmina Gallardo Jose M. Sánchez-Vizcaíno Jose M. Sánchez-Vizcaíno Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
description	African swine fever (ASF) is a highly lethal infectious disease that affects domestic pigs and wild boar. Outbreaks of ASF have grown considerably in the last decade causing important economic consequences for the swine industry. Its control is hampered by the lack of an effective treatment or vaccine. In Europe, the wild boar is a key wild reservoir for ASF. The results of the oral vaccination trial of wild boar with Lv17/WB/Rie1 are hope for this problem. However, this vaccine candidate has certain safety concerns, since it is a naturally attenuated vaccine. Therefore, the current study aims to evaluate the safety of this vaccine candidate in terms of overdose (high dose) and repeated doses (revaccination) in wild boar. Low-dose orally vaccinated animals developed only a slight transient fever after vaccination and revaccination. This was also the case for most of the high-dose vaccinated wild boar, except for one of them which succumbed after revaccination. Although this fatality was related to hierarchical fights between animals, we consider that further studies are required for clarification. Considering these new results and the current epidemiological situation of ASF in wild boar, this vaccine prototype is a promising tool for the control of the disease in these wild populations, although further studies are needed.
format	article
author	Jose A. Barasona Jose A. Barasona Estefanía Cadenas-Fernández Estefanía Cadenas-Fernández Aleksandra Kosowska Aleksandra Kosowska Sandra Barroso-Arévalo Sandra Barroso-Arévalo Belén Rivera Belén Rivera Rocío Sánchez Rocío Sánchez Néstor Porras Carmina Gallardo Jose M. Sánchez-Vizcaíno Jose M. Sánchez-Vizcaíno
author_facet	Jose A. Barasona Jose A. Barasona Estefanía Cadenas-Fernández Estefanía Cadenas-Fernández Aleksandra Kosowska Aleksandra Kosowska Sandra Barroso-Arévalo Sandra Barroso-Arévalo Belén Rivera Belén Rivera Rocío Sánchez Rocío Sánchez Néstor Porras Carmina Gallardo Jose M. Sánchez-Vizcaíno Jose M. Sánchez-Vizcaíno
author_sort	Jose A. Barasona
title	Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_short	Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_full	Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_fullStr	Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_full_unstemmed	Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses
title_sort	safety of african swine fever vaccine candidate lv17/wb/rie1 in wild boar: overdose and repeated doses
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bc5201d121a34e75a0698ec347093055
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Safety of African Swine Fever Vaccine Candidate Lv17/WB/Rie1 in Wild Boar: Overdose and Repeated Doses

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