Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifyi...

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Autores principales:	Nilah M. Ioannidis, Wei Wang, Nicholas A. Furlotte, David A. Hinds, 23andMe Research Team, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari, Alice S. Whittemore
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bc53e2b17a3e44f0b9062dcd5eaac15b
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spelling	oai:doaj.org-article:bc53e2b17a3e44f0b9062dcd5eaac15b2021-12-02T17:32:00ZGene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma10.1038/s41467-018-06149-62041-1723https://doaj.org/article/bc53e2b17a3e44f0b9062dcd5eaac15b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06149-6https://doaj.org/toc/2041-1723Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifying five novel genetic loci linked to cSCC susceptibility.Nilah M. IoannidisWei WangNicholas A. FurlotteDavid A. Hinds23andMe Research TeamCarlos D. BustamanteEric JorgensonMaryam M. AsgariAlice S. WhittemoreNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nilah M. Ioannidis Wei Wang Nicholas A. Furlotte David A. Hinds 23andMe Research Team Carlos D. Bustamante Eric Jorgenson Maryam M. Asgari Alice S. Whittemore Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
description	Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS). Here, the authors impute gene expression levels from GWAS data to perform a transcriptome wide association study (TWAS), identifying five novel genetic loci linked to cSCC susceptibility.
format	article
author	Nilah M. Ioannidis Wei Wang Nicholas A. Furlotte David A. Hinds 23andMe Research Team Carlos D. Bustamante Eric Jorgenson Maryam M. Asgari Alice S. Whittemore
author_facet	Nilah M. Ioannidis Wei Wang Nicholas A. Furlotte David A. Hinds 23andMe Research Team Carlos D. Bustamante Eric Jorgenson Maryam M. Asgari Alice S. Whittemore
author_sort	Nilah M. Ioannidis
title	Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
title_short	Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
title_full	Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
title_fullStr	Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
title_full_unstemmed	Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
title_sort	gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bc53e2b17a3e44f0b9062dcd5eaac15b
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Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

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