Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review

Hepatitis A virus immunoglobulin M (HAV-IgM) is often used to diagnose acute hepatitis A virus (HAV) infection serologically. However, false-positive test results can interfere with the diagnosis. A 56-year-old woman was readmitted to the hospital owing to abnormal liver function tests for the last...

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Autores principales:	Tan Youwen, Chen Li
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	immunoglobulin m hepatitis a false-positive Medicine R
Acceso en línea:	https://doaj.org/article/bc5407785ff445e3baecaf69912bf639
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spelling	oai:doaj.org-article:bc5407785ff445e3baecaf69912bf6392021-12-05T14:10:55ZSustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review2391-546310.1515/med-2021-0336https://doaj.org/article/bc5407785ff445e3baecaf69912bf6392021-09-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0336https://doaj.org/toc/2391-5463Hepatitis A virus immunoglobulin M (HAV-IgM) is often used to diagnose acute hepatitis A virus (HAV) infection serologically. However, false-positive test results can interfere with the diagnosis. A 56-year-old woman was readmitted to the hospital owing to abnormal liver function tests for the last 18 months. She had been diagnosed with acute HAV and was hospitalized in isolation based on a positive HAV-IgM test 18 months ago. Regular follow-up after discharge showed abnormal liver function and an elevated level of antinuclear antibodies and immunoglobulin G. For the last 15 days, the patient had fatigue, decreased appetite, and yellow urine, signaling recrudescence. Liver function tests were also abnormal. Liver biopsy revealed histological changes consistent with typical autoimmune hepatitis. After 2 months of methylprednisolone treatment, liver function returned to normal, and HAV-IgM turned negative. The diagnosis of acute HAV in nonendemic areas requires a comprehensive analysis of epidemic history, clinical characteristics, etiology, etc.Tan YouwenChen LiDe Gruyterarticleimmunoglobulin mhepatitis afalse-positiveMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1311-1317 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunoglobulin m hepatitis a false-positive Medicine R
spellingShingle	immunoglobulin m hepatitis a false-positive Medicine R Tan Youwen Chen Li Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review
description	Hepatitis A virus immunoglobulin M (HAV-IgM) is often used to diagnose acute hepatitis A virus (HAV) infection serologically. However, false-positive test results can interfere with the diagnosis. A 56-year-old woman was readmitted to the hospital owing to abnormal liver function tests for the last 18 months. She had been diagnosed with acute HAV and was hospitalized in isolation based on a positive HAV-IgM test 18 months ago. Regular follow-up after discharge showed abnormal liver function and an elevated level of antinuclear antibodies and immunoglobulin G. For the last 15 days, the patient had fatigue, decreased appetite, and yellow urine, signaling recrudescence. Liver function tests were also abnormal. Liver biopsy revealed histological changes consistent with typical autoimmune hepatitis. After 2 months of methylprednisolone treatment, liver function returned to normal, and HAV-IgM turned negative. The diagnosis of acute HAV in nonendemic areas requires a comprehensive analysis of epidemic history, clinical characteristics, etiology, etc.
format	article
author	Tan Youwen Chen Li
author_facet	Tan Youwen Chen Li
author_sort	Tan Youwen
title	Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review
title_short	Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review
title_full	Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review
title_fullStr	Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review
title_full_unstemmed	Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review
title_sort	sustained false-positive results for hepatitis a virus immunoglobulin m: a case report and literature review
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/bc5407785ff445e3baecaf69912bf639
work_keys_str_mv	AT tanyouwen sustainedfalsepositiveresultsforhepatitisavirusimmunoglobulinmacasereportandliteraturereview AT chenli sustainedfalsepositiveresultsforhepatitisavirusimmunoglobulinmacasereportandliteraturereview
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Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review

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