A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dependent blood vessel development.

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Autores principales: Davide Pradella, Gianluca Deflorian, Alex Pezzotta, Anna Di Matteo, Elisa Belloni, Daniele Campolungo, Andrea Paradisi, Mattia Bugatti, William Vermi, Matteo Campioni, Antonella Chiapparino, Luigi Scietti, Federico Forneris, Costanza Giampietro, Nina Volf, Michael Rehman, Serena Zacchigna, Maria Paola Paronetto, Anna Pistocchi, Anne Eichmann, Patrick Mehlen, Claudia Ghigna
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bc552c64149c47869cf73be5501499a0
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spelling oai:doaj.org-article:bc552c64149c47869cf73be5501499a02021-12-02T15:08:12ZA ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis10.1038/s41467-021-24998-62041-1723https://doaj.org/article/bc552c64149c47869cf73be5501499a02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24998-6https://doaj.org/toc/2041-1723UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dependent blood vessel development.Davide PradellaGianluca DeflorianAlex PezzottaAnna Di MatteoElisa BelloniDaniele CampolungoAndrea ParadisiMattia BugattiWilliam VermiMatteo CampioniAntonella ChiapparinoLuigi SciettiFederico FornerisCostanza GiampietroNina VolfMichael RehmanSerena ZacchignaMaria Paola ParonettoAnna PistocchiAnne EichmannPatrick MehlenClaudia GhignaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Davide Pradella
Gianluca Deflorian
Alex Pezzotta
Anna Di Matteo
Elisa Belloni
Daniele Campolungo
Andrea Paradisi
Mattia Bugatti
William Vermi
Matteo Campioni
Antonella Chiapparino
Luigi Scietti
Federico Forneris
Costanza Giampietro
Nina Volf
Michael Rehman
Serena Zacchigna
Maria Paola Paronetto
Anna Pistocchi
Anne Eichmann
Patrick Mehlen
Claudia Ghigna
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
description UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dependent blood vessel development.
format article
author Davide Pradella
Gianluca Deflorian
Alex Pezzotta
Anna Di Matteo
Elisa Belloni
Daniele Campolungo
Andrea Paradisi
Mattia Bugatti
William Vermi
Matteo Campioni
Antonella Chiapparino
Luigi Scietti
Federico Forneris
Costanza Giampietro
Nina Volf
Michael Rehman
Serena Zacchigna
Maria Paola Paronetto
Anna Pistocchi
Anne Eichmann
Patrick Mehlen
Claudia Ghigna
author_facet Davide Pradella
Gianluca Deflorian
Alex Pezzotta
Anna Di Matteo
Elisa Belloni
Daniele Campolungo
Andrea Paradisi
Mattia Bugatti
William Vermi
Matteo Campioni
Antonella Chiapparino
Luigi Scietti
Federico Forneris
Costanza Giampietro
Nina Volf
Michael Rehman
Serena Zacchigna
Maria Paola Paronetto
Anna Pistocchi
Anne Eichmann
Patrick Mehlen
Claudia Ghigna
author_sort Davide Pradella
title A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
title_short A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
title_full A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
title_fullStr A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
title_full_unstemmed A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
title_sort ligand-insensitive unc5b splicing isoform regulates angiogenesis by promoting apoptosis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bc552c64149c47869cf73be5501499a0
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