Impact of metabolic syndrome and its components on bone remodeling in adolescents.

<h4>Introduction</h4>Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures.<h4>Objective</h4>To evaluate t...

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Autores principales:	Valéria Nóbrega da Silva, Tamara Beres Lederer Goldberg, Carla Cristiane Silva, Cilmery Suemi Kurokawa, Luciana Nunes Mosca Fiorelli, Anapaula da Conceição Bisi Rizzo, José Eduardo Corrente
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc57c55617254ac3ae3503d6ad1bbf03
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spelling	oai:doaj.org-article:bc57c55617254ac3ae3503d6ad1bbf032021-12-02T20:09:46ZImpact of metabolic syndrome and its components on bone remodeling in adolescents.1932-620310.1371/journal.pone.0253892https://doaj.org/article/bc57c55617254ac3ae3503d6ad1bbf032021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253892https://doaj.org/toc/1932-6203<h4>Introduction</h4>Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures.<h4>Objective</h4>To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight.<h4>Method</h4>A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx).<h4>Results</h4>The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = < .000), and S-CTx (r = -0.53838; p = 0.011) in girls.<h4>Conclusion</h4>Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight.Valéria Nóbrega da SilvaTamara Beres Lederer GoldbergCarla Cristiane SilvaCilmery Suemi KurokawaLuciana Nunes Mosca FiorelliAnapaula da Conceição Bisi RizzoJosé Eduardo CorrentePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253892 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valéria Nóbrega da Silva Tamara Beres Lederer Goldberg Carla Cristiane Silva Cilmery Suemi Kurokawa Luciana Nunes Mosca Fiorelli Anapaula da Conceição Bisi Rizzo José Eduardo Corrente Impact of metabolic syndrome and its components on bone remodeling in adolescents.
description	<h4>Introduction</h4>Osteoporosis and metabolic syndrome (MetS) are diseases that have serious public health consequences, reducing the quality of life of patients and increasing morbidity and mortality, with substantial healthcare expenditures.<h4>Objective</h4>To evaluate the impact of MetS on bone mineral density (BMD) and biochemical markers of bone formation and resorption in adolescents with excess weight.<h4>Method</h4>A descriptive and analytical cross-sectional study was performed that evaluated 271 adolescents of both sexes (10 to 16 years). From the total sample, 42 adolescents with excess weight and the presence of MetS (14%) were selected. A further 42 adolescents with excess weight and without MetS were chosen, matched for chronological age, bone age, and pubertal developmental criteria to those with MetS, for each sex. Anthropometric measurements, blood pressure collection, and biochemical tests were performed in all adolescents, as well as evaluation of BMD and the bone biomarkers osteocalcin (OC), bone alkaline phosphatase (BAP), and carboxy-terminal telopeptide (S-CTx).<h4>Results</h4>The adolescents with excess weight and MetS exhibited significantly lower transformed BMD and concentrations of BAP, OC, and S-CTx compared to the matched group, except for OC in boys. A negative and significant correlation was observed between total body BMD and BAP (r = -0.55568; p = 0.005), OC (r = -0.81760; p = < .000), and S-CTx (r = -0.53838; p = 0.011) in girls.<h4>Conclusion</h4>Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight.
format	article
author	Valéria Nóbrega da Silva Tamara Beres Lederer Goldberg Carla Cristiane Silva Cilmery Suemi Kurokawa Luciana Nunes Mosca Fiorelli Anapaula da Conceição Bisi Rizzo José Eduardo Corrente
author_facet	Valéria Nóbrega da Silva Tamara Beres Lederer Goldberg Carla Cristiane Silva Cilmery Suemi Kurokawa Luciana Nunes Mosca Fiorelli Anapaula da Conceição Bisi Rizzo José Eduardo Corrente
author_sort	Valéria Nóbrega da Silva
title	Impact of metabolic syndrome and its components on bone remodeling in adolescents.
title_short	Impact of metabolic syndrome and its components on bone remodeling in adolescents.
title_full	Impact of metabolic syndrome and its components on bone remodeling in adolescents.
title_fullStr	Impact of metabolic syndrome and its components on bone remodeling in adolescents.
title_full_unstemmed	Impact of metabolic syndrome and its components on bone remodeling in adolescents.
title_sort	impact of metabolic syndrome and its components on bone remodeling in adolescents.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bc57c55617254ac3ae3503d6ad1bbf03
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Impact of metabolic syndrome and its components on bone remodeling in adolescents.

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