Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.

<h4>Background</h4>Infections may increase the risk for venous thromboembolism (VTE), but little is known about VTE risk associated with community-acquired bacteraemia (CAB). We examined the risk for VTE within one year of CAB in comparison to that in matched controls.<h4>Methods&l...

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Autores principales:	Michael Dalager-Pedersen, Mette Søgaard, Henrik C Schønheyder, Reimar W Thomsen, John A Baron, Henrik Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc58bef9bcb04d338dedee1a0994af32
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spelling	oai:doaj.org-article:bc58bef9bcb04d338dedee1a0994af322021-11-18T08:36:12ZVenous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.1932-620310.1371/journal.pone.0086094https://doaj.org/article/bc58bef9bcb04d338dedee1a0994af322014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465892/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Infections may increase the risk for venous thromboembolism (VTE), but little is known about VTE risk associated with community-acquired bacteraemia (CAB). We examined the risk for VTE within one year of CAB in comparison to that in matched controls.<h4>Methods</h4>We conducted a population-based cohort study in North Denmark 1992-2011, using data from high-quality health-care databases. We included 4,213 adult CAB patients who had positive blood cultures drawn on the day of hospital admission, 20,084 matched hospitalised controls admitted for other acute medical illness, and 41,121 matched controls from the general population. We computed 0-90 and 91-365 day absolute risks for hospital-diagnosed VTE and used regression analyses with adjustment for confounding factors to compare the risk for VTE in bacteraemia patients and controls.<h4>Results</h4>Among CAB patients, 1.1% experienced VTE within 90 days of admission and 0.5% during 91-365 days after admission. The adjusted 90-day odds ratio (OR) for VTE was 1.9 (95% CI 1.4-2.7) compared with hospitalised controls, and 23.4 (95% CI 12.9-42.6) compared with population controls. During 91-365 days after CAB admission, the VTE risk remained moderately increased (adjusted hazard ratio vs. hospitalised controls, 1.4; 95% CI 0.8-2.5, and vs. population controls, 1.9; 95% CI 1.0-3.3). Compared to hospitalised controls, the 90-day VTE risk increase was greater for Gram-positive infection (adjusted OR 2.5; 95% CI 1.6-4.1) than for Gram-negative infection (adjusted OR, 1.2; 95% CI 0.7-2.1), partly due to a high risk after Staphylococcus aureus infection (3.6%).<h4>Conclusion</h4>The risk for VTE is substantially increased within 90 days after community-acquired bacteraemia when compared to hospitalised controls and population controls. However, the absolute risk of VTE following CAB is low.Michael Dalager-PedersenMette SøgaardHenrik C SchønheyderReimar W ThomsenJohn A BaronHenrik NielsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86094 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Dalager-Pedersen Mette Søgaard Henrik C Schønheyder Reimar W Thomsen John A Baron Henrik Nielsen Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
description	<h4>Background</h4>Infections may increase the risk for venous thromboembolism (VTE), but little is known about VTE risk associated with community-acquired bacteraemia (CAB). We examined the risk for VTE within one year of CAB in comparison to that in matched controls.<h4>Methods</h4>We conducted a population-based cohort study in North Denmark 1992-2011, using data from high-quality health-care databases. We included 4,213 adult CAB patients who had positive blood cultures drawn on the day of hospital admission, 20,084 matched hospitalised controls admitted for other acute medical illness, and 41,121 matched controls from the general population. We computed 0-90 and 91-365 day absolute risks for hospital-diagnosed VTE and used regression analyses with adjustment for confounding factors to compare the risk for VTE in bacteraemia patients and controls.<h4>Results</h4>Among CAB patients, 1.1% experienced VTE within 90 days of admission and 0.5% during 91-365 days after admission. The adjusted 90-day odds ratio (OR) for VTE was 1.9 (95% CI 1.4-2.7) compared with hospitalised controls, and 23.4 (95% CI 12.9-42.6) compared with population controls. During 91-365 days after CAB admission, the VTE risk remained moderately increased (adjusted hazard ratio vs. hospitalised controls, 1.4; 95% CI 0.8-2.5, and vs. population controls, 1.9; 95% CI 1.0-3.3). Compared to hospitalised controls, the 90-day VTE risk increase was greater for Gram-positive infection (adjusted OR 2.5; 95% CI 1.6-4.1) than for Gram-negative infection (adjusted OR, 1.2; 95% CI 0.7-2.1), partly due to a high risk after Staphylococcus aureus infection (3.6%).<h4>Conclusion</h4>The risk for VTE is substantially increased within 90 days after community-acquired bacteraemia when compared to hospitalised controls and population controls. However, the absolute risk of VTE following CAB is low.
format	article
author	Michael Dalager-Pedersen Mette Søgaard Henrik C Schønheyder Reimar W Thomsen John A Baron Henrik Nielsen
author_facet	Michael Dalager-Pedersen Mette Søgaard Henrik C Schønheyder Reimar W Thomsen John A Baron Henrik Nielsen
author_sort	Michael Dalager-Pedersen
title	Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
title_short	Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
title_full	Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
title_fullStr	Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
title_full_unstemmed	Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
title_sort	venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/bc58bef9bcb04d338dedee1a0994af32
work_keys_str_mv	AT michaeldalagerpedersen venousthromboembolismaftercommunityacquiredbacteraemiaa20yeardanishcohortstudy AT mettesøgaard venousthromboembolismaftercommunityacquiredbacteraemiaa20yeardanishcohortstudy AT henrikcschønheyder venousthromboembolismaftercommunityacquiredbacteraemiaa20yeardanishcohortstudy AT reimarwthomsen venousthromboembolismaftercommunityacquiredbacteraemiaa20yeardanishcohortstudy AT johnabaron venousthromboembolismaftercommunityacquiredbacteraemiaa20yeardanishcohortstudy AT henriknielsen venousthromboembolismaftercommunityacquiredbacteraemiaa20yeardanishcohortstudy
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Venous thromboembolism after community-acquired bacteraemia: a 20-year danish cohort study.

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