Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.

Serum zinc (Zn) levels tend to be low in chronic kidney disease (CKD) patients. This cohort study was conducted to investigate the relationship between zinc deficiency and CKD progression. Patients were classified into two groups based on Zn levels < 60 μg/dl (low-Zn group, n = 160) and ≥ 60 μg/d...

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Autores principales:	Atsuyuki Tokuyama, Eiichiro Kanda, Seiji Itano, Megumi Kondo, Yoshihisa Wada, Hiroyuki Kadoya, Kengo Kidokoro, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc5a6f9e82204b89bd7af3b0365ee5ed
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spelling	oai:doaj.org-article:bc5a6f9e82204b89bd7af3b0365ee5ed2021-12-02T20:04:07ZEffect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.1932-620310.1371/journal.pone.0251554https://doaj.org/article/bc5a6f9e82204b89bd7af3b0365ee5ed2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251554https://doaj.org/toc/1932-6203Serum zinc (Zn) levels tend to be low in chronic kidney disease (CKD) patients. This cohort study was conducted to investigate the relationship between zinc deficiency and CKD progression. Patients were classified into two groups based on Zn levels < 60 μg/dl (low-Zn group, n = 160) and ≥ 60 μg/dl (high-Zn group, n = 152). The primary outcome was defined as end-stage kidney disease (ESKD) or death and was examined over a 1-year observation period. Overall, the mean Zn level was 59.6 μg/dl and the median eGFR was 20.3 ml/min/1.73 m2. The incidence of the primary outcome was higher in the low-Zn group (p<0.001). Various Cox proportional hazards models adjusted for baseline characteristics showed higher risks of the primary outcome in the low-Zn group than in the high-Zn group. Competing risks analysis showed that low Zn levels were associated with ESKD but not with death. Moreover, in propensity score-matched analysis, the low-Zn group showed a higher risk of the primary outcome [adjusted hazard ratio 1.81 (95% confidence interval 1.02, 3.24)]. Furthermore, an interaction was observed between Zn and serum albumin levels (interaction p = 0.026). The results of this study indicate that zinc deficiency is a risk factor for CKD progression.Atsuyuki TokuyamaEiichiro KandaSeiji ItanoMegumi KondoYoshihisa WadaHiroyuki KadoyaKengo KidokoroHajime NagasuTamaki SasakiNaoki KashiharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsuyuki Tokuyama Eiichiro Kanda Seiji Itano Megumi Kondo Yoshihisa Wada Hiroyuki Kadoya Kengo Kidokoro Hajime Nagasu Tamaki Sasaki Naoki Kashihara Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
description	Serum zinc (Zn) levels tend to be low in chronic kidney disease (CKD) patients. This cohort study was conducted to investigate the relationship between zinc deficiency and CKD progression. Patients were classified into two groups based on Zn levels < 60 μg/dl (low-Zn group, n = 160) and ≥ 60 μg/dl (high-Zn group, n = 152). The primary outcome was defined as end-stage kidney disease (ESKD) or death and was examined over a 1-year observation period. Overall, the mean Zn level was 59.6 μg/dl and the median eGFR was 20.3 ml/min/1.73 m2. The incidence of the primary outcome was higher in the low-Zn group (p<0.001). Various Cox proportional hazards models adjusted for baseline characteristics showed higher risks of the primary outcome in the low-Zn group than in the high-Zn group. Competing risks analysis showed that low Zn levels were associated with ESKD but not with death. Moreover, in propensity score-matched analysis, the low-Zn group showed a higher risk of the primary outcome [adjusted hazard ratio 1.81 (95% confidence interval 1.02, 3.24)]. Furthermore, an interaction was observed between Zn and serum albumin levels (interaction p = 0.026). The results of this study indicate that zinc deficiency is a risk factor for CKD progression.
format	article
author	Atsuyuki Tokuyama Eiichiro Kanda Seiji Itano Megumi Kondo Yoshihisa Wada Hiroyuki Kadoya Kengo Kidokoro Hajime Nagasu Tamaki Sasaki Naoki Kashihara
author_facet	Atsuyuki Tokuyama Eiichiro Kanda Seiji Itano Megumi Kondo Yoshihisa Wada Hiroyuki Kadoya Kengo Kidokoro Hajime Nagasu Tamaki Sasaki Naoki Kashihara
author_sort	Atsuyuki Tokuyama
title	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
title_short	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
title_full	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
title_fullStr	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
title_full_unstemmed	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
title_sort	effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bc5a6f9e82204b89bd7af3b0365ee5ed
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Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.

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