The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors

Due to increasing life expectancy, low-cost interventions to counteract age-related memory impairment have gained popularity. Physical activity has been shown to positively affect memory and hippocampal plasticity in rodents and humans. These effects have been proposed to be mediated by the release...

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Autores principales: Laura A. Kuhne, Anna-Maria Ksiezarczyk, Klaus-Michael Braumann, Rüdiger Reer, Thomas Jacobs, Brigitte Röder, Kirsten Hötting
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Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:bc5ad464da314d87968d3d84c6e9baf82021-11-08T05:42:52ZThe Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors1663-436510.3389/fnagi.2021.750401https://doaj.org/article/bc5ad464da314d87968d3d84c6e9baf82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.750401/fullhttps://doaj.org/toc/1663-4365Due to increasing life expectancy, low-cost interventions to counteract age-related memory impairment have gained popularity. Physical activity has been shown to positively affect memory and hippocampal plasticity in rodents and humans. These effects have been proposed to be mediated by the release of neurotrophic factors. However, studies examining the effects of a single cardiovascular exercise session on human memory have yielded conflicting results. Moreover, it remains unclear whether exercise-induced memory enhancements are related to changes in peripheral neurotrophic factor concentrations. The present study tested whether one bout of cardiovascular exercise during an early phase of memory consolidation, compared to one bout of stretching and toning, positively affected memory. Furthermore, it was analyzed whether exercise-induced changes in the brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were related to memory enhancement after a single bout of physical exercise. Fifty healthy participants (20–40 years) were randomly assigned to either a cycling group (BIKE) or a stretching and toning group (STRETCH). Participants performed an implicit vocabulary learning task which was immediately followed by physical exercise. Memory for the learned vocabulary was tested 1–2 weeks later. To measure exercise-induced changes in serum neurotrophic factor levels, blood samples were collected at rest (baseline) and immediately after the exercise session. Results did not show a significant difference in memory between the BIKE group and the STRETCH group. However, in the BIKE group, a larger increase in BDNF and VEGF levels was observed than in the STRETCH group. Moreover, the increase in BDNF and memory performance tended to be positively related in the BIKE group. We speculate that the correlation between exercise-increased BDNF levels and memory in the cycling group may indicate an involvement of BDNF in mediating memory processes after acute cardiovascular exercise.Laura A. KuhneAnna-Maria KsiezarczykKlaus-Michael BraumannRüdiger ReerThomas JacobsBrigitte RöderKirsten HöttingFrontiers Media S.A.articlelearningmemoryphysical exerciseneurotrophic factorsBDNFVEGFNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution DOAJ
collection DOAJ
language EN
topic learning
memory
physical exercise
neurotrophic factors
BDNF
VEGF
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle learning
memory
physical exercise
neurotrophic factors
BDNF
VEGF
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Laura A. Kuhne
Anna-Maria Ksiezarczyk
Klaus-Michael Braumann
Rüdiger Reer
Thomas Jacobs
Brigitte Röder
Kirsten Hötting
The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
description Due to increasing life expectancy, low-cost interventions to counteract age-related memory impairment have gained popularity. Physical activity has been shown to positively affect memory and hippocampal plasticity in rodents and humans. These effects have been proposed to be mediated by the release of neurotrophic factors. However, studies examining the effects of a single cardiovascular exercise session on human memory have yielded conflicting results. Moreover, it remains unclear whether exercise-induced memory enhancements are related to changes in peripheral neurotrophic factor concentrations. The present study tested whether one bout of cardiovascular exercise during an early phase of memory consolidation, compared to one bout of stretching and toning, positively affected memory. Furthermore, it was analyzed whether exercise-induced changes in the brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were related to memory enhancement after a single bout of physical exercise. Fifty healthy participants (20–40 years) were randomly assigned to either a cycling group (BIKE) or a stretching and toning group (STRETCH). Participants performed an implicit vocabulary learning task which was immediately followed by physical exercise. Memory for the learned vocabulary was tested 1–2 weeks later. To measure exercise-induced changes in serum neurotrophic factor levels, blood samples were collected at rest (baseline) and immediately after the exercise session. Results did not show a significant difference in memory between the BIKE group and the STRETCH group. However, in the BIKE group, a larger increase in BDNF and VEGF levels was observed than in the STRETCH group. Moreover, the increase in BDNF and memory performance tended to be positively related in the BIKE group. We speculate that the correlation between exercise-increased BDNF levels and memory in the cycling group may indicate an involvement of BDNF in mediating memory processes after acute cardiovascular exercise.
format article
author Laura A. Kuhne
Anna-Maria Ksiezarczyk
Klaus-Michael Braumann
Rüdiger Reer
Thomas Jacobs
Brigitte Röder
Kirsten Hötting
author_facet Laura A. Kuhne
Anna-Maria Ksiezarczyk
Klaus-Michael Braumann
Rüdiger Reer
Thomas Jacobs
Brigitte Röder
Kirsten Hötting
author_sort Laura A. Kuhne
title The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
title_short The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
title_full The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
title_fullStr The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
title_full_unstemmed The Effects of Acute Cardiovascular Exercise on Memory and Its Associations With Exercise-Induced Increases in Neurotrophic Factors
title_sort effects of acute cardiovascular exercise on memory and its associations with exercise-induced increases in neurotrophic factors
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/bc5ad464da314d87968d3d84c6e9baf8
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