Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study
Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to det...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:bc5bb801b82d4899b21796eb49ad13c52021-11-11T10:22:06ZAlteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study1662-516110.3389/fnhum.2021.762343https://doaj.org/article/bc5bb801b82d4899b21796eb49ad13c52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.762343/fullhttps://doaj.org/toc/1662-5161Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12–17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT. Following ECT, the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) significantly decreased in the right precentral gyrus, and the degree centrality (DC) decreased in the left triangular part of the inferior frontal gyrus and increased in the left hippocampus. There were significant negative correlations between the change of HAMD (ΔHAMD) and ALFF in the right precentral gyrus at baseline, and between the change of BSSI and the change of fALFF in the right precentral gyrus. The ΔHAMD was positively correlated with the DC value of the left hippocampus at baseline. We suggest that these brain regions may be indicators of response to ECT in adolescents with MDD and SI.Xiao LiRenqiang YuQian HuangXiaolu ChenMing AiYi ZhouLinqi DaiXiaoyue QinLi KuangFrontiers Media S.A.articleMDDadolescentALFFdegree centralityresting-state fMRIsuicidal ideationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021) |
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MDD adolescent ALFF degree centrality resting-state fMRI suicidal ideation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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MDD adolescent ALFF degree centrality resting-state fMRI suicidal ideation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xiao Li Renqiang Yu Qian Huang Xiaolu Chen Ming Ai Yi Zhou Linqi Dai Xiaoyue Qin Li Kuang Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study |
| description |
Major depressive disorder (MDD) is one of the most widespread mental disorders and can result in suicide. Suicidal ideation (SI) is strongly predictive of death by suicide, and electroconvulsive therapy (ECT) is effective for MDD, especially in patients with SI. In the present study, we aimed to determine differences in resting-state functional magnetic resonance imaging (rs-fMRI) in 14 adolescents aged 12–17 with MDD and SI at baseline and after ECT. All participants were administered the Hamilton Depression Scale (HAMD) and Beck Scale for Suicide Ideation (BSSI) and received rs-fMRI scans at baseline and after ECT. Following ECT, the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) significantly decreased in the right precentral gyrus, and the degree centrality (DC) decreased in the left triangular part of the inferior frontal gyrus and increased in the left hippocampus. There were significant negative correlations between the change of HAMD (ΔHAMD) and ALFF in the right precentral gyrus at baseline, and between the change of BSSI and the change of fALFF in the right precentral gyrus. The ΔHAMD was positively correlated with the DC value of the left hippocampus at baseline. We suggest that these brain regions may be indicators of response to ECT in adolescents with MDD and SI. |
| format |
article |
| author |
Xiao Li Renqiang Yu Qian Huang Xiaolu Chen Ming Ai Yi Zhou Linqi Dai Xiaoyue Qin Li Kuang |
| author_facet |
Xiao Li Renqiang Yu Qian Huang Xiaolu Chen Ming Ai Yi Zhou Linqi Dai Xiaoyue Qin Li Kuang |
| author_sort |
Xiao Li |
| title |
Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study |
| title_short |
Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study |
| title_full |
Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study |
| title_fullStr |
Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study |
| title_full_unstemmed |
Alteration of Whole Brain ALFF/fALFF and Degree Centrality in Adolescents With Depression and Suicidal Ideation After Electroconvulsive Therapy: A Resting-State fMRI Study |
| title_sort |
alteration of whole brain alff/falff and degree centrality in adolescents with depression and suicidal ideation after electroconvulsive therapy: a resting-state fmri study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/bc5bb801b82d4899b21796eb49ad13c5 |
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