Functional diversity and structural disorder in the human ubiquitination pathway.

The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several hundred E3 (ubiquitin ligase) enzymes. By col...

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Autores principales: Pallab Bhowmick, Rita Pancsa, Mainak Guharoy, Peter Tompa
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/bc5e98eb2c4f4b26bf02a7a8619e70d1
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