Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.

Slow-wave sleep cortical brain activity, conformed by slow-oscillations and sleep spindles, plays a key role in memory consolidation. The increase of the power of the slow-wave events, obtained by auditory sensory stimulation, positively correlates with memory consolidation performance. However, lit...

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Autores principales:	Felipe A Torres, Patricio Orio, María-José Escobar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bc61e6ecc0f94e81b8630c1c22c73751
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spelling	oai:doaj.org-article:bc61e6ecc0f94e81b8630c1c22c737512021-12-02T19:57:30ZSelection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.1553-734X1553-735810.1371/journal.pcbi.1008758https://doaj.org/article/bc61e6ecc0f94e81b8630c1c22c737512021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1008758https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Slow-wave sleep cortical brain activity, conformed by slow-oscillations and sleep spindles, plays a key role in memory consolidation. The increase of the power of the slow-wave events, obtained by auditory sensory stimulation, positively correlates with memory consolidation performance. However, little is known about the experimental protocol maximizing this effect, which could be induced by the power of slow-oscillation, the number of sleep spindles, or the timing of both events' co-occurrence. Using a mean-field model of thalamocortical activity, we studied the effect of several stimulation protocols, varying the pulse shape, duration, amplitude, and frequency, as well as a target-phase using a closed-loop approach. We evaluated the effect of these parameters on slow-oscillations (SO) and sleep-spindles (SP), considering: (i) the power at the frequency bands of interest, (ii) the number of SO and SP, (iii) co-occurrences between SO and SP, and (iv) synchronization of SP with the up-peak of the SO. The first three targets are maximized using a decreasing ramp pulse with a pulse duration of 50 ms. Also, we observed a reduction in the number of SO when increasing the stimulus energy by rising its amplitude. To assess the target-phase parameter, we applied closed-loop stimulation at 0°, 45°, and 90° of the phase of the narrow-band filtered ongoing activity, at 0.85 Hz as central frequency. The 0° stimulation produces better results in the power and number of SO and SP than the rhythmic or random stimulation. On the other hand, stimulating at 45° or 90° change the timing distribution of spindles centers but with fewer co-occurrences than rhythmic and 0° phase. Finally, we propose the application of closed-loop stimulation at the rising zero-cross point using pulses with a decreasing ramp shape and 50 ms of duration for future experimental work.Felipe A TorresPatricio OrioMaría-José EscobarPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1008758 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Felipe A Torres Patricio Orio María-José Escobar Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
description	Slow-wave sleep cortical brain activity, conformed by slow-oscillations and sleep spindles, plays a key role in memory consolidation. The increase of the power of the slow-wave events, obtained by auditory sensory stimulation, positively correlates with memory consolidation performance. However, little is known about the experimental protocol maximizing this effect, which could be induced by the power of slow-oscillation, the number of sleep spindles, or the timing of both events' co-occurrence. Using a mean-field model of thalamocortical activity, we studied the effect of several stimulation protocols, varying the pulse shape, duration, amplitude, and frequency, as well as a target-phase using a closed-loop approach. We evaluated the effect of these parameters on slow-oscillations (SO) and sleep-spindles (SP), considering: (i) the power at the frequency bands of interest, (ii) the number of SO and SP, (iii) co-occurrences between SO and SP, and (iv) synchronization of SP with the up-peak of the SO. The first three targets are maximized using a decreasing ramp pulse with a pulse duration of 50 ms. Also, we observed a reduction in the number of SO when increasing the stimulus energy by rising its amplitude. To assess the target-phase parameter, we applied closed-loop stimulation at 0°, 45°, and 90° of the phase of the narrow-band filtered ongoing activity, at 0.85 Hz as central frequency. The 0° stimulation produces better results in the power and number of SO and SP than the rhythmic or random stimulation. On the other hand, stimulating at 45° or 90° change the timing distribution of spindles centers but with fewer co-occurrences than rhythmic and 0° phase. Finally, we propose the application of closed-loop stimulation at the rising zero-cross point using pulses with a decreasing ramp shape and 50 ms of duration for future experimental work.
format	article
author	Felipe A Torres Patricio Orio María-José Escobar
author_facet	Felipe A Torres Patricio Orio María-José Escobar
author_sort	Felipe A Torres
title	Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
title_short	Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
title_full	Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
title_fullStr	Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
title_full_unstemmed	Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
title_sort	selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bc61e6ecc0f94e81b8630c1c22c73751
work_keys_str_mv	AT felipeatorres selectionofstimulusparametersforenhancingslowwavesleepeventswithaneuralfieldtheorythalamocorticalmodel AT patricioorio selectionofstimulusparametersforenhancingslowwavesleepeventswithaneuralfieldtheorythalamocorticalmodel AT mariajoseescobar selectionofstimulusparametersforenhancingslowwavesleepeventswithaneuralfieldtheorythalamocorticalmodel
_version_	1718375863691509760

Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.

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