How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity

Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechani...

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Auteurs principaux:	Laurie-Anne Lamotte, Lionel Tafforeau
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	influenza A virus NS1 ubiquitin SUMO ISG NEDD8 Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/bc625331524541df900e379a205d1636
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spelling	oai:doaj.org-article:bc625331524541df900e379a205d16362021-11-25T19:14:27ZHow Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity10.3390/v131123091999-4915https://doaj.org/article/bc625331524541df900e379a205d16362021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2309https://doaj.org/toc/1999-4915Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host’s antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review.Laurie-Anne LamotteLionel TafforeauMDPI AGarticleinfluenza A virusNS1ubiquitinSUMOISGNEDD8MicrobiologyQR1-502ENViruses, Vol 13, Iss 2309, p 2309 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	influenza A virus NS1 ubiquitin SUMO ISG NEDD8 Microbiology QR1-502
spellingShingle	influenza A virus NS1 ubiquitin SUMO ISG NEDD8 Microbiology QR1-502 Laurie-Anne Lamotte Lionel Tafforeau How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
description	Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host’s antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review.
format	article
author	Laurie-Anne Lamotte Lionel Tafforeau
author_facet	Laurie-Anne Lamotte Lionel Tafforeau
author_sort	Laurie-Anne Lamotte
title	How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_short	How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_full	How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_fullStr	How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_full_unstemmed	How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity
title_sort	how influenza a virus ns1 deals with the ubiquitin system to evade innate immunity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bc625331524541df900e379a205d1636
work_keys_str_mv	AT laurieannelamotte howinfluenzaavirusns1dealswiththeubiquitinsystemtoevadeinnateimmunity AT lioneltafforeau howinfluenzaavirusns1dealswiththeubiquitinsystemtoevadeinnateimmunity
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How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity

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