Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.

Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.

Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas. Rapamycin inhibits mammalian target of rapamycin (mTOR) protein, which is often expressed in human aden...

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Autores principales: Karin M Hardiman, Jianhua Liu, Ying Feng, Joel K Greenson, Eric R Fearon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/bc62b423af1d46478dfd2895a237726f
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