Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels

Abstract We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed...

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Autores principales:	Guilherme Debortoli, Gilderlanio Santana de Araujo, Cesar Fortes-Lima, Esteban J. Parra, Guilherme Suarez-Kurtz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc65d5fa3cd84b5483bf7beb99802eb7
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spelling	oai:doaj.org-article:bc65d5fa3cd84b5483bf7beb99802eb72021-12-02T14:01:22ZIdentification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels10.1038/s41598-020-80389-92045-2322https://doaj.org/article/bc65d5fa3cd84b5483bf7beb99802eb72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80389-9https://doaj.org/toc/2045-2322Abstract We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.Guilherme DebortoliGilderlanio Santana de AraujoCesar Fortes-LimaEsteban J. ParraGuilherme Suarez-KurtzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guilherme Debortoli Gilderlanio Santana de Araujo Cesar Fortes-Lima Esteban J. Parra Guilherme Suarez-Kurtz Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
description	Abstract We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.
format	article
author	Guilherme Debortoli Gilderlanio Santana de Araujo Cesar Fortes-Lima Esteban J. Parra Guilherme Suarez-Kurtz
author_facet	Guilherme Debortoli Gilderlanio Santana de Araujo Cesar Fortes-Lima Esteban J. Parra Guilherme Suarez-Kurtz
author_sort	Guilherme Debortoli
title	Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_short	Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_full	Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_fullStr	Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_full_unstemmed	Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
title_sort	identification of ancestry proportions in admixed groups across the americas using clinical pharmacogenomic snp panels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc65d5fa3cd84b5483bf7beb99802eb7
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Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels

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