The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature

William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depressi...

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Autores principales:	Nicholson WC, Kempf MC, Moneyham L, Vance DE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	tVNS depression HIV vagus nerve HIV-associated neurocognitive disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bc6717c6569a42f796feffbe05ac0028
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spelling	oai:doaj.org-article:bc6717c6569a42f796feffbe05ac00282021-12-02T06:25:48ZThe potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature1178-2021https://doaj.org/article/bc6717c6569a42f796feffbe05ac00282017-06-01T00:00:00Zhttps://www.dovepress.com/the-potential-role-of-vagus-nerve-stimulation-in-the-treatment-of-hiv--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike. Interestingly, the parasympathetic system-associated vagus nerve (VN) has primary homeostatic properties that restore CNS function following a stress or inflammatory response. Unfortunately, about 30% of adults with HIV are resistant to standard psychotherapeutic and psychopharmacological treatments for depression, thus suggesting the need for alternative treatment approaches. VN stimulation (VNS) and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population. Historically, VNS has been delivered using a surgically implanted device; however, transcutanous VNS (tVNS) with nonsurgical auricular technology is now available. Although it currently lacks Food and Drug Administration approval in the US, evidence suggests several advantages of tVNS, including a reduced side-effect profile when compared to standard treatments and comparable results to implantable VNS in treating depression. Therefore, tVNS could offer an alternative for managing depression in HIV via regulating CNS function; moreover, tVNS may be useful for treatment of other symptoms common in HIV. From this, implications for nursing research and practice are provided. Keywords: tVNS, depression, HIV, vagus nerveNicholson WCKempf MCMoneyham LVance DEDove Medical PressarticletVNSdepressionHIVvagus nerveHIV-associated neurocognitive disordersNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1677-1689 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	tVNS depression HIV vagus nerve HIV-associated neurocognitive disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	tVNS depression HIV vagus nerve HIV-associated neurocognitive disorders Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nicholson WC Kempf MC Moneyham L Vance DE The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
description	William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike. Interestingly, the parasympathetic system-associated vagus nerve (VN) has primary homeostatic properties that restore CNS function following a stress or inflammatory response. Unfortunately, about 30% of adults with HIV are resistant to standard psychotherapeutic and psychopharmacological treatments for depression, thus suggesting the need for alternative treatment approaches. VN stimulation (VNS) and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population. Historically, VNS has been delivered using a surgically implanted device; however, transcutanous VNS (tVNS) with nonsurgical auricular technology is now available. Although it currently lacks Food and Drug Administration approval in the US, evidence suggests several advantages of tVNS, including a reduced side-effect profile when compared to standard treatments and comparable results to implantable VNS in treating depression. Therefore, tVNS could offer an alternative for managing depression in HIV via regulating CNS function; moreover, tVNS may be useful for treatment of other symptoms common in HIV. From this, implications for nursing research and practice are provided. Keywords: tVNS, depression, HIV, vagus nerve
format	article
author	Nicholson WC Kempf MC Moneyham L Vance DE
author_facet	Nicholson WC Kempf MC Moneyham L Vance DE
author_sort	Nicholson WC
title	The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
title_short	The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
title_full	The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
title_fullStr	The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
title_full_unstemmed	The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
title_sort	potential role of vagus-nerve stimulation in the treatment of hiv-associated depression: a review of literature
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/bc6717c6569a42f796feffbe05ac0028
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The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature

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