Cellular forces and matrix assembly coordinate fibrous tissue repair
Planar in vitromodels for wound closure stress the role of lamellipodial protrusions and purse-string contraction. Here the authors develop a 3D biomimetic model for tissue repair and show a mode of stromal closure that relies on whole tissue deformations, cell migration and matrix deposition.
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Main Authors: | Mahmut Selman Sakar, Jeroen Eyckmans, Roel Pieters, Daniel Eberli, Bradley J. Nelson, Christopher S. Chen |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
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Subjects: | |
Online Access: | https://doaj.org/article/bc6809c44db74a4f8e56024976f8197c |
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