Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum

Sandhanasamy Devanesan,1,2 Karuppiah Ponmurugan,3 Mohamad S AlSalhi,1,2 Naif Abdullah Al-Dhabi3 1Research Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Physics and Astronomy, College of Science,...

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Autores principales:	Devanesan S, Ponmurugan K, AlSalhi MS, Al-Dhabi NA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	asafoetida gum agnps antimicrobial cytotoxicity biomedical agent Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bc695989cccf4aa6899ed88253ecf56e
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spelling	oai:doaj.org-article:bc695989cccf4aa6899ed88253ecf56e2021-12-02T08:20:22ZCytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum1178-2013https://doaj.org/article/bc695989cccf4aa6899ed88253ecf56e2020-06-01T00:00:00Zhttps://www.dovepress.com/cytotoxic-and-antimicrobial-efficacy-of-silver-nanoparticles-synthesiz-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sandhanasamy Devanesan,1,2 Karuppiah Ponmurugan,3 Mohamad S AlSalhi,1,2 Naif Abdullah Al-Dhabi3 1Research Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh 11451, Saudi ArabiaCorrespondence: Mohamad S AlSalhiResearch Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaEmail malsalhi@ksu.edu.saPurpose: The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties.Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively.Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6– 8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50- and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained.Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.Keywords: asafoetida gum, AgNPs, antimicrobial, cytotoxicity, biomedical agentDevanesan SPonmurugan KAlSalhi MSAl-Dhabi NADove Medical Pressarticleasafoetida gumagnpsantimicrobialcytotoxicitybiomedical agentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4351-4362 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	asafoetida gum agnps antimicrobial cytotoxicity biomedical agent Medicine (General) R5-920
spellingShingle	asafoetida gum agnps antimicrobial cytotoxicity biomedical agent Medicine (General) R5-920 Devanesan S Ponmurugan K AlSalhi MS Al-Dhabi NA Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum
description	Sandhanasamy Devanesan,1,2 Karuppiah Ponmurugan,3 Mohamad S AlSalhi,1,2 Naif Abdullah Al-Dhabi3 1Research Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh 11451, Saudi ArabiaCorrespondence: Mohamad S AlSalhiResearch Chair in Laser Diagnosis of Cancer, Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaEmail malsalhi@ksu.edu.saPurpose: The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties.Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively.Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6– 8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50- and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained.Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.Keywords: asafoetida gum, AgNPs, antimicrobial, cytotoxicity, biomedical agent
format	article
author	Devanesan S Ponmurugan K AlSalhi MS Al-Dhabi NA
author_facet	Devanesan S Ponmurugan K AlSalhi MS Al-Dhabi NA
author_sort	Devanesan S
title	Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum
title_short	Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum
title_full	Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum
title_fullStr	Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum
title_full_unstemmed	Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum
title_sort	cytotoxic and antimicrobial efficacy of silver nanoparticles synthesized using a traditional phytoproduct, asafoetida gum
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bc695989cccf4aa6899ed88253ecf56e
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Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum

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